Automation is the replacement of human manipulative effort by mechanical and instrumental devices that are regulated by feedback of information so that an apparatus is self-monitoring or self-adjusting. Clinical laboratory hematology deal with the analysis of normal and pathologic blood cells either in the peripheral blood or in the hematopoietic tissue (i.e. tissues that produce the blood). Also it may be extended to include cells in cerebrospinal and serous fluid. Moreover, laboratory hematology also analyzes the hemostatic condition. This book provides a simple overview of automation in hematology and its principles, with the substantial contribution made by the automated instruments in the sensitive detection of various abnormalities, and the provision of novel parameters that critically help in the correct and accurate diagnosis and classification of a wide variety of hematological diseases. These advances definitely aid the timely and proper treatment of disease conditions.