In present situation cancer became a cruel reality to human lives due to their resistance to accessible drugs. Thus, discovery of new types of anticancer drugs becomes very critical.Heterocyclic entities act as medications since they have precise synthetic reactivity and they give advantageous site to which bioactive substituents can be bind. Subsequently, there is need for the improvement of pharmacologically active heterocycles in synthetic and therapeutic science with certain focal points including its effortlessness of activity, greener methodology, simple workup strategy, selectivity, higher yields and high-particleMonetary.The role of Benzimidazole and Isoindole derivatives in drug design and synthesis of pharmacologically important molecules has grown enormously worldwide.Benzimidazole and Isoindole derivatives have received attention due to their remarkable biological activities. These scaffolds have been consistently rewarded as a promising versatile lead molecule with apivotal position in modern medicinal chemistry.A major aim of this book was to provide recent anticancer activity of Benzimidazole and Isoindole