Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

Herausgeber: El-Khatib, Aiman Saad and of Pharmacology and Toxicology; Khattab, Mahmoud Mohamed; Mansour, Heba Mohamed

• Broschiertes Buch

Produktbeschreibung

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders.

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Produktdetails

• Verlag: Elsevier Science Publishing Co Inc
• Seitenzahl: 604
• Erscheinungstermin: 8. Juni 2023
• Englisch
• Abmessung: 199mm x 242mm x 34mm
• Gewicht: 1254g
• ISBN-13: 9780443186776
• ISBN-10: 0443186774
• Artikelnr.: 67368442

Inhaltsangabe

1. The Molecular Pathology of Neurodegenerative And Psychiatric Disorders
2. Receptor Tyrosine Kinases: An Overview 3. Roles of TRK Receptors,
Tyrosine Kinase Receptors for Neurotrophins, in the Developing CNS 4.
Receptor Tyrosine Kinase (RTKs): from biology to pathophysiology 5. Growth
Factors and Their Receptors: Multitasking Functionality in Health and
Disease 6. Regulation of Receptor Tyrosine Kinase Gene Expression 7. Role
Of Receptor Tyrosine Kinases in Neurodegenerative Disorders 8. Insights
into Receptor Tyrosine Kinase Signaling in Neurodegenerative Disorders:
Opportunities and Translational Perspectives 9. Receptor Tyrosine Kinases
in Major Depressive Disorder 10. Repositioning of Receptor Tyrosine Kinase
Inhibitors: From Cancer to Neurodegenerative And Psychiatric Disorders 11.
Protein Kinase Inhibitors as Therapeutics in Neurodegenerative and
Psychiatric Disorders: Progress, Challenges, and Recommendations