Introduction: Despite the growing awareness of problems associated with referrals and feedback system among health care providers there is no study conducted to improve referral and feedback in primary and tertiary level health care providers.Objective: Assess knowledge of referral and feedback system among higher level health care provider in primary and tertiary level healthcare providers Amhara region, Ethiopia.Method: An institutional based cross-sectional study was conducted among primary and tertiary level health care, Amhara region. Random sampling technique used to select 223 participants. Bivariabl and multivariable logistic regression performed to see the effects of each variable.Result: More than half (54.7%) of higher level health care providers had good knowledge of referral system. Only (15.2%) (95% CI: 10, 20) of respondents had good knowledge of feedback. Factor associated with knowledge of referral system was interdepartmental protocol [AOR: = 2.2, 95% CI: (1.08,4.51)]. Sex [AOR: =4.5, CI 95%(1.03- 19.97)], follow up (AOR= 2.40, CI 95%).
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