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This project was based on the portfolio developed during the specialization, in which learning was based on daily experience and the construction of new knowledge was through the constructive spiral teaching model. In this way, patient safety centers aim to ensure patient safety within institutions throughout the entire health-disease process, from admission to discharge. Protocols and actions must be implemented in patient care, with a focus on care free of Adverse Events. The exchange of experience between the actors showed that the realities and difficulties are the same, whether financial, breaking paradigms or cultural change. Therefore, in order for there to be a change in attitude, all the players involved in the patient care process must: speak the same language and financial resources must be directed to this sector. However, humanization and continuing education are the crucial points for achieving success and continuity in Patient Safety within healthcare institutions.