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This material was initially produced as a technical manual to support a specialised outpatient clinic in a psychiatry residency service in the city of São José dos Pinhais, Paraná, Brazil. After being publicised at a local scientific event, it was proposed for publication and became a book. Through concise approaches, it brings together relevant information that is extremely important for the daily clinical practice of psychiatrists who treat patients with refractory schizophrenia.