Muscle wasting diseases affect millions of people worldwide leading to impaired function in activities of their daily life. The treatment of the idiopathic myopathies is still largely empirical. Recently, a new era of using helminthic therapy in many diseases has been emerged. Although T. spiralis infection induces moderate myopathic changes in the muscles; there is possible relationship between T. spiralis muscle larval invasion and the subsequent muscle regeneration produced. This relation could be used as a novel helminthic therapy to ameliorate the severity of idiopathic autoimmune myopathy. This book could help anyone interest in studying the therapeutic effect of T. spiralis and its antigens. Also, it could help anyone interest in discovery a new line of therapy for idiopathic myopathy.