Regenerative Medicine for Degenerative Muscle Diseases
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This book compiles andexplores cutting-edge research in degenerative skeletal disorders, such asDuchenne muscular dystrophy and congenital myopathy, and new stem-cell basedtherapies and gene replacement therapy. Twelve expertly-authored chapters navigatethe nuances of these treatments in an array of contexts and biological systems.The topics covered include: How are urine cells from a patient with Duchennemuscular dystrophy transformed into beating heart cells? What can reprogrammedcells tell us about heart muscle failure? What do gene mutations mean for thoseborn with a muscle disease? How…mehr

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Produktbeschreibung
This book compiles andexplores cutting-edge research in degenerative skeletal disorders, such asDuchenne muscular dystrophy and congenital myopathy, and new stem-cell basedtherapies and gene replacement therapy. Twelve expertly-authored chapters navigatethe nuances of these treatments in an array of contexts and biological systems.The topics covered include: How are urine cells from a patient with Duchennemuscular dystrophy transformed into beating heart cells? What can reprogrammedcells tell us about heart muscle failure? What do gene mutations mean for thoseborn with a muscle disease? How are manufacturing methods applied to human stemcells? Does therapeutic exercise benefit those patients who receive engineeredlimb muscle? Is there practical advice about nutrition to enhance musclefunction for the Duchenne patient? Can microRNAs be useful to regeneratediseased muscle?

RegenerativeMedicine for Degenerative Muscle Diseases is ideal for scientistsand clinicians from varying disciplines in genetics, cell biology, virology,cell-based manufacturing, rehabilitation medicine, nutrition, veterinarymedicine and neurosurgery. The reader will see how transformative changes occurin medicine that can powerfully impact the future for patients suffering frominherited disorders affecting muscles of the body, including the heart.

Autorenporträt
Martin K. (Casey) Childers, D.O., Ph.D.  is a professor in the Department of Rehabilitation Medicine and Investigator at the Institute for Stem Cell & Regenerative Medicine, University of Washington. He is a graduate of Seattle Pacific University  (B.A., Music Performance), Western University (D.O., Medicine, Osteopathic) and The University of Missouri (Ph.D., Physiology & Pharmacology; residency, Rehabilitation Medicine). The Childers' laboratory works in two areas of investigation. In a series of preclinical studies, they address the hurdles required for systemic gene replacement delivery for patients with X-Linked Myotubular Myopathy (XLMTM). In other studies, they use a "disease in a dish" approach with induced pluripotent stem (iPS) cells to study heart disease in patients with Duchenne muscular dystrophy (DMD). Dr. Childers clinical medicine practice at the University of Washington Medical Center is dedicated to serve patients with neuromuscular diseases.