The time seems ripe for a critical compendum of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This…mehr
The time seems ripe for a critical compendum of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Genetics of Polyoma Virus and Simian Virus 40.- 1. Introduction.- 2. Restriction Enzyme Maps of the Polyoma and SV40 Genomes.- 3. The Lytic Growth Cycle.- 4. Mutants of Polyoma and SV40.- 5. Viral Functions and the Early Region of the Genome.- 6. Temperature-Dependent Properties of Transformed Cells.- 7. References.- 2 Genetics of Adenoviruses.- 1. Introduction.- 2. Adenovirus Mutants.- 3. Characteristics of the Adenovirus Genetic System.- 4. Phenotypes of Adenovirus Mutants.- 5. Functional Studies Using Adenovirus Mutants.- 6. Critique and Perspectives.- 7. Note Added in Proof.- 8. References.- 3 Genetics of Herpesviruses.- 1. Introduction.- 2. Virus Mutants.- 3. Characterization of Mutants.- 4. Recombination.- 5. Effective Genomes.- 6. Validity of Recombination Analysis.- 7. The Genes of HSV.- 8. Mixed-Morphology Plaques.- 9. Transformation.- 10. Latency.- 11. References.- 4 Genetics of Picornaviruses.- 1. Introduction.- 2. Definition of a Picornavirus.- 3. The Schizon.- 4. Classification of Picornaviruses.- 5. Genetic Methods.- 6. Interactions of Picornavirus Genomes.- 7. The Genetic Recombination Map of Picornaviruses.- 8. Relation of Genetic Map to Gene Functions.- 9. Relation of Genetic Map to Gene Products.- 10. Sites of Action of Viral Growth Inhibitors.- 11. The Strategy of the Picornavirus Genome.- 12. Conclusions.- 13. References.- 5 Genetics of Togaviruses.- 1. Review of the Structure and Replication of Group A Togaviruses.- 2. Types of Mutants.- 3. Interactions of Togavirus Mutants in Mixed Infections.- 4. Physiological Defects in Temperature-Sensitive Mutants.- 5. References.- 6 Genetics of Rhabdoviruses.- 1. Introduction: Some Relevant Biological Features of Rhabdoviruses.- 2. Coding Capacity of the Genome of Rhabdoviruses.- 3. Rhabdovirus Mutants.- 4.Absence of Recombination.- 5. Complementation.- 6. Temperature-Sensitive Mutants in the Analysis of Genome Function.- 7. Defectiveness.- 8. Phenotypic Mixing and Pseudotypes.- 9. Host-Controlled Modification.- 10. Virulence and Persistent Infection.- 11. Sigma Virus and Germinal Transmission.- 12. Future Prospects.- 13. References.- 7 Genetics of Reoviruses.- 1. Introduction: Structure and Replication of Reoviruses as They Relate to Genetics.- 2. Genetic Interactions.- 3. Gene Function.- 4. Effect on Host.- 5. References.- 8 Genetics of RNA Tumor Viruses.- 1. Introduction 341 1.1. Scope of This Chapter.- 2. Basic Properties of the Virus Genome.- 3. Nonconditional Mutants and Markers.- 4. Interactions between RNA Tumor Viruses.- 5. Conditional Mutants.- 6. Biochemical Approaches to RNA Tumor Virus Genetics.- 7. Concluding Speculations.- 8. References.- 9 Genetics and Paragenetic Phenomena of Paramyxoviruses.- 1. Introduction.- 2. Properties Relevant to Genetic Analyses.- 3. Virus Populations.- 4. Origins of Mutants and Variants.- 5. Types of Mutants and Variants.- 6. Genetic and Paragenetic Phenomena.- 7. Temperature-Sensitive Mutants.- 8. Persistent Infection.- 9. Other Directions.- 10. References.- 10 Genetics of Orthomyxoviruses.- 1. Introduction.- 2. Molecular Biology of the Genome.- 3. Virus Population.- 4. Temperature-Sensitive Mutants.- 5. Conclusion.- 6. References.
1 Genetics of Polyoma Virus and Simian Virus 40.- 1. Introduction.- 2. Restriction Enzyme Maps of the Polyoma and SV40 Genomes.- 3. The Lytic Growth Cycle.- 4. Mutants of Polyoma and SV40.- 5. Viral Functions and the Early Region of the Genome.- 6. Temperature-Dependent Properties of Transformed Cells.- 7. References.- 2 Genetics of Adenoviruses.- 1. Introduction.- 2. Adenovirus Mutants.- 3. Characteristics of the Adenovirus Genetic System.- 4. Phenotypes of Adenovirus Mutants.- 5. Functional Studies Using Adenovirus Mutants.- 6. Critique and Perspectives.- 7. Note Added in Proof.- 8. References.- 3 Genetics of Herpesviruses.- 1. Introduction.- 2. Virus Mutants.- 3. Characterization of Mutants.- 4. Recombination.- 5. Effective Genomes.- 6. Validity of Recombination Analysis.- 7. The Genes of HSV.- 8. Mixed-Morphology Plaques.- 9. Transformation.- 10. Latency.- 11. References.- 4 Genetics of Picornaviruses.- 1. Introduction.- 2. Definition of a Picornavirus.- 3. The Schizon.- 4. Classification of Picornaviruses.- 5. Genetic Methods.- 6. Interactions of Picornavirus Genomes.- 7. The Genetic Recombination Map of Picornaviruses.- 8. Relation of Genetic Map to Gene Functions.- 9. Relation of Genetic Map to Gene Products.- 10. Sites of Action of Viral Growth Inhibitors.- 11. The Strategy of the Picornavirus Genome.- 12. Conclusions.- 13. References.- 5 Genetics of Togaviruses.- 1. Review of the Structure and Replication of Group A Togaviruses.- 2. Types of Mutants.- 3. Interactions of Togavirus Mutants in Mixed Infections.- 4. Physiological Defects in Temperature-Sensitive Mutants.- 5. References.- 6 Genetics of Rhabdoviruses.- 1. Introduction: Some Relevant Biological Features of Rhabdoviruses.- 2. Coding Capacity of the Genome of Rhabdoviruses.- 3. Rhabdovirus Mutants.- 4.Absence of Recombination.- 5. Complementation.- 6. Temperature-Sensitive Mutants in the Analysis of Genome Function.- 7. Defectiveness.- 8. Phenotypic Mixing and Pseudotypes.- 9. Host-Controlled Modification.- 10. Virulence and Persistent Infection.- 11. Sigma Virus and Germinal Transmission.- 12. Future Prospects.- 13. References.- 7 Genetics of Reoviruses.- 1. Introduction: Structure and Replication of Reoviruses as They Relate to Genetics.- 2. Genetic Interactions.- 3. Gene Function.- 4. Effect on Host.- 5. References.- 8 Genetics of RNA Tumor Viruses.- 1. Introduction 341 1.1. Scope of This Chapter.- 2. Basic Properties of the Virus Genome.- 3. Nonconditional Mutants and Markers.- 4. Interactions between RNA Tumor Viruses.- 5. Conditional Mutants.- 6. Biochemical Approaches to RNA Tumor Virus Genetics.- 7. Concluding Speculations.- 8. References.- 9 Genetics and Paragenetic Phenomena of Paramyxoviruses.- 1. Introduction.- 2. Properties Relevant to Genetic Analyses.- 3. Virus Populations.- 4. Origins of Mutants and Variants.- 5. Types of Mutants and Variants.- 6. Genetic and Paragenetic Phenomena.- 7. Temperature-Sensitive Mutants.- 8. Persistent Infection.- 9. Other Directions.- 10. References.- 10 Genetics of Orthomyxoviruses.- 1. Introduction.- 2. Molecular Biology of the Genome.- 3. Virus Population.- 4. Temperature-Sensitive Mutants.- 5. Conclusion.- 6. References.
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