Regulation of the exchange activity of Dbl-family proteins - Yohe, Marielle
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Dbl-related oncoproteins are guanine nucleotide exchange factors (GEFs) specific for Rho-family GTPases and typically possess tandem Dbl (DH) and pleckstrin homology (PH) domains that act in concert to catalyze exchange. The exchange activities of many Dbl-proteins are regulated by phosphorylation or constitutively activated by truncations preceding their DH domains. However, exact mechanisms of regulation remain poorly understood. The current literature regarding the activation and inhibition of the exchange activity of the human Dbl-family proteins is reviewed here, with a focus on general mechanisms of regulation common to many of these proteins.…mehr

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Produktbeschreibung
Dbl-related oncoproteins are guanine nucleotide
exchange factors (GEFs) specific for Rho-family
GTPases and typically possess tandem Dbl (DH) and
pleckstrin homology (PH) domains that act in concert
to catalyze exchange. The exchange activities of
many Dbl-proteins are regulated by phosphorylation or
constitutively activated by truncations preceding
their DH domains. However, exact mechanisms of
regulation remain poorly understood. The current
literature regarding the activation and inhibition of
the exchange activity of the human Dbl-family
proteins is reviewed here, with a focus on general
mechanisms of regulation common to many of these
proteins.
Autorenporträt
Marielle Yohe received her B.A. in chemistry in 1999 from
Wellesley College. She received her Ph.D. in Pharmacology in
2007 and her M.D. in 2009 from the University of North Carolina
at Chapel Hill. She is currently a resident physician in
pediatrics at the Connecticut Children s Medical Center. She
lives in Connecticut with her husband.