O. David Sherwood

Relaxin and Related Peptides

Fourth International Conference, Volume 1041
Herausgeber: Sherwood, O David; Steinetz, Bernard G; Fields, Phillip A

• Broschiertes Buch

Produktbeschreibung

Relaxin is a protein hormone, produced and secreted during pregnancy in mammalian species, having superficial structural features resembling those of insulin. Since its initial isolation from the ovaries of pregnant pigs in 1976, increasing interest in relaxin has led to increased understanding of the chemistry, synthesis, secretion, biological roles, mechanisms of action, and potential clinical applications of relaxin in humans and domestic animals. In pigs, rats, and mice, relaxin promotes growth and softening of the cervix, enabling rapid and safe delivery of the fetuses. In these species relaxin also promotes growth and development of the mammary apparatus. Recently, biological effects of relaxin in the heart, kidney, liver, and brain have been identified, and these discoveries have triggered additional interest in possible clinical applications for relaxin. In 2002, a second form of relaxin, which is found primarily in the brain, was discovered. Relaxin-like factor (also called insulin 3), which was discovered in 1993, is produced in the fetal testis and plays a major role in testicular descent during development. The recent identification of the receptors for both relaxin and relaxin-like factor has enabled more rigorous studies of the target tissues and mechanisms of action of these hormones. This volume contains a description of recent advances and future research and clinical possibilities in the field of relaxin and related peptides. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

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Produktdetails

• Verlag: Wiley
• Revised edition
• Seitenzahl: 544
• Erscheinungstermin: 1. Juni 2005
• Englisch
• Abmessung: 229mm x 153mm x 25mm
• Gewicht: 767g
• ISBN-13: 9781573314855
• ISBN-10: 1573314854
• Artikelnr.: 23837079

Autorenporträt

O. David Sherwood is with the University of Illinois at Urbana-Champaign in Urbana, Illinois, USA. Phillip A. Fields is with the University of South Alabama in Mobile, Alabama, USA.

Inhaltsangabe

Preface (O David Sherwood). Young Investigator Award Recipients. Remembrance: Edmund S. Crelin (1923-2004) (Bernard G. Steinetz). Opening Remarks: An "Old Hand's" Perspective of Relaxin 2004's Place Along the Relaxin Trail (O David Sherwood). In Memoriam: Robert L. Kroc-A Relaxin Pioneer and So Much More (Bernard G. Steinetz). Part I: Structure/Activity Aspects of Relaxin
Relaxin-Related Peptides
and Their Receptors. 1. Relaxin Research in the Postgenomic Era (Kazuhiro Kawamura
Satoko Sudo
Jin Kumagai
Margareta Pisarska
Sheau Yu Teddy Hsu
Ross Bathgate
John Wade
And Aaron J. W. Hsueh). 2. Characterization of the Mouse and Rat Relaxin Receptors (D J Scott
S Layfield
A Riesewijk
H Morita
G W Tregear
And R A D Bathgate). 3. Characterization of the Rat INSL3 Receptor (D J Scott
P Fu
P-J Shen
A Gundlach
S Layfield
A Riesewijk
H Tomiyama
J M Hutson
G W Tregear
And R A D Bathgate). 4. Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors (Michelle L. Halls
Ross A. Bathgate
Satoko Sudo
Jin Kumagai
Courtney P. Bond
And Roger J. Summers). 5. LGR7-Truncate Is a Splice Variant of the Relaxin Receptor LGR7 and Is a Relaxin Antagonist in Vitro (D J Scott
G W Tregear
And R A D Bathgate). 6. The Human LGR7 Low-Density Lipoprotein Class A Module Requires Calcium for Structure (Emma J. Hopkins
Ross A. Bathgate
And Paul R. Gooley). 7. Studies on Soluble Ectodomain Proteins of Relaxin (LGR7) and Insulin 3 (LGR8) Receptors (Yan Yan
Jin Cai
Ping Fu
Sharon Layfield
Tania Ferraro
Jin Kumagai
Satoko Sudo
Jian-Guo Tang
Eleni Giannakis
Geoffrey W. Tregear
John D. Wade
And Ross A.D. Bathgate). 8. The Chemistry and Biology of Human Relaxin-3 (Geoffrey W. Tregear
Ross A. Bathgate
Sharon Layfield
Tania Ferraro
Andrew Gundlach
Sherie Ma
Feng Lin
Nicola F. Hanson
Roger J. Summers
Johan Rosengren
David J. Craik
And John D. Wade). 9. Recent Progress in Relaxin-3-Related Research (Changlu Liu
Pascal Bonaventure
Steven W. Sutton
Jingcai Chen
Chester Kuei
Diane Nepomuceno
and Timothy W. Lovenberg). 10. Receptors for Relaxin Family Peptides (Ross A. Bathgate
Richard Ivell
Barbara M. Sanborn
O David Sherwood
And Roger J. Summers). 11. Expression of Porcine Prorelaxin in Transgenic Tobacco (Scott Buswell
Fabricio Medina-Bolivar
Qiang Chen
Kevin Van Cott
And Chenming Zhang). Part IIA: Actions of Relaxin: Reproductive Tissues during Pregnancy. 12. Genetic Targeting of Relaxin and Insl3 Signaling in Mice (Shu Feng
Natalia V. Bogatcheva
Aparna A. Kamat
And Alexander I. Agoulnik). 13. Mechanisms of Relaxin Action in the Reproductive Tract: Studies in the Relaxin-Deficient (Rlx-/-) Mouse (Laura J. Parry
Jonathan T. McGuane
Helen M. Gehring
Irna Grace T. Kostic
and Andrew L. Siebel). 14. Oxytocin and Estrogen Receptor Expression in the Myometrium of Pregnant Relaxin-Deficient (Rlx-/-) Mice (Andrew L. Siebel
Helen M. Gehring
Lenka Vodstrcil
And Laura J. Parry). 15. Relaxin Regulates Endometrial Structure and Function in the Rhesus Monkey (Laura T. Goldsmith And Gerson Weiss). 16. Effects of the Sucking Stimulus on Relaxin Receptor (LGR7) Expression in the Mammary Apparatus of the Tammar Wallaby (Macropus eugenii) (Janey Gwyther
Helen M. Gehring
and Laura J. Parry). 17. Potential Binding Sites for Relaxin in Pregnant Rabbits (Phillip A. Fields and Michael J. Fields). Part IIB: Actions of Relaxin: Reproductive Tissues in Nonpregnant Animals. 18. Porcine and Human Relaxin Bioactivity: Bioactivities of Porcine Relaxin and Human Relaxin Do Not Differ in Mice and Rats (Shuangping Zhao
Hyung-Yul Lee
and O D Sherwood). 19. Tissue-Specific Effects of Relaxin on the Reproductive Tract of Neonatal Gilts (Wenbo Yan
Anne A. Wiley
Frank F. Bartol
And Carol A. Bagnell). 20. Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle (Courtney P. Bond
Laura J. Parry
Chrishan S. Samuel
Helen M. Gehring
Fiona L. Lederman
Peter A. W. Rogers
and Roger J. Summers). 21. Relaxin-Induced Angiogenesis in Ovary Contributes to Follicle Development (Kyoko Shirota
Kayoko Tateishi
Makoto Emoto
Toru Hachisuga
Masahide Kuroki
and Tatsuhiko Kawarabayashi). Part IIIA: Actions of Relaxin in Nonreproductive Tissues: Hemodynamic
Osmoregulatory
and Antifibrotic. 22. Role of Relaxin in Maternal Renal Vasodilation of Pregnancy (Kirk P. Conrad
Arun Jeyabalan
Leslie A. Danielson
Laurie J. Kerchner
And Jacqueline Novak). 23. Recombinant Human Relaxin (rhRLX) Modifies Systemic Arterial Properties in Conscious Rats Irrespective of Gender
but in a Biphasic Fashion (Dan O. Debrah
Kirk P. Conrad
Jackie Novak
Lee A. Danielson
And Sanjeev G. Shroff). 24. Renal Hemodynamic Effects of Relaxin in Humans (Marie Smith
John Davison
Kirk Conrad
And Lee Danielson). 25. The Relaxin Gene-Knockout Mouse: A Model of Progressive Fibrosis (Chrishan S. Samuel
Chongxin Zhao
Ross A.D. Bathgate
Xiao-Jun Du
Roger J. Summers
Edward P. Amento
Lesley L. Walker
Mary Mcburnie
Ling Zhao
And Geoffrey W. Tregear). 26. Relaxin Regulates Collagen Overproduction Associated with Experimental Progressive Renal Fibrosis (Chrishan S. Samuel
Ishanee Mookerjee
Rosemary Masterson
Geoffrey W. Tregear
And Tim D. Hewitson). 27. Relaxin Receptor Expression in Hepatic Stellate Cells and in Cirrhotic Rat Liver Tissue (Robert G. Bennett
Katrina J. Mahan
Martha J. Gentry-Nielsen
And Dean J. Tuma). 28. Relaxin Modulates Fibroblast Function
Collagen Production
and Matrix Metalloproteinase-2 Expression by Cardiac Fibroblasts (Ishanee Mookerjee
Elaine N. Unemori
Xiao-Jun Du
Geoffrey W. Tregear
and Chrishan S. Samuel). 29. Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease (Ishanee Mookerjee
Mimi L.K. Tang
Natasha Solly
Geoffrey W. Tregear
And Chrishan S. Samuel). Part IIIB: Actions of Relaxin in Nonreproductive Tissues: Central Actions. 30. Localization of LGR7 Gene Expression in Adult Mouse Brain Using LGR7 Knock-out/LacZ Knock-in Mice: Correlation with LGR7 mRNA Distribution (Loretta Piccenna
Pei-Juan Shen
Sherie Ma
Tanya C. D. Burazin
Jan A. Gossen
Sietse Mosselman
Ross A. D. Bathgate
and Andrew L. Gundlach). 31. Localization of LGR7 (Relaxin Receptor) mRNA and Protein in Rat Forebrain: Correlation with Relaxin Binding Site Distribution (Tanya C.D. Burazin
Kelli J. Johnson
Sherie Ma
Ross A.D. Bathgate
Geoffrey W. Tregear
and Andrew L. Gundlach). 32. Insulin-Relaxin Family Peptide Signaling and Receptors in Mouse Brain Membranes and Neuronal Cells (Stefanie Ortinau
Feng Lin
John D. Wade
Geoffrey W. Tregear
Ross A.D. Bathgate
And Andrew L. Gundlach). 33. Central Effects of Long-Term Relaxin Expression in the Rat (Josh D. Silvertown
Russell Fraser
Roman S. Poterski
Brad Geddes
and Alastair J.S. Summerlee). 34. Relaxin Pretreatment Decreases Infarct Size in Male Rats after Middle Cerebral Artery Occlusion (Brian C. Wilson
Peter Milne
And Tarek M. Saleh). 35. Relaxin Inhibits Central Angiotensin II Expression in Killifish: A Central Osmoregulatory Role for Relaxin and Angiotensin II in the Killifish Fundulus heteroclitus (Adwoa Amamoo and Brian C. Wilson). Part IVA: Relaxin-Induced Signal Transduction: Interaction of Relaxin and Steroid Signaling. 36. New Insight into the Transcriptional Regulation of Vascular Endothelial Growth Factor Expression in the Endometrium by Estrogen and Relaxin: Robert D. Koos
Armina A. Kazi
Mark S. Roberson
and Jenny M. Jones). 37. Effects of Relaxin on Neonatal Porcine Uterine Growth and Development: Carol A. Bagnell
Wenbo Yan
Anne A. Wiley
And Frank F. Bartol). 38. The Pregnancy Hormone Relaxin Binds to and Activates the Human Glucocorticoid Receptor: Thomas Dschietzig
Cornelia Bartsch
Michael Greinwald
Gert Baumann
and Karl Stangl). Part IVB: Relaxin-Induced Signal Transduction: Relaxin Stimulates Multiple Signal Transduction Pathways. 39. Relaxin Stimulates Multiple Signaling Pathways: Activation of cAMP
PI3K
and PKC in THP-1 Cells (Carmen W. Dessauer and Bao T. Nguyen). 40. Relaxin Signaling from Natural Receptors (Richard Ivell
Ravinder Anand-Ivell
and Olaf Bartsch). 41. Signal Switching after Stimulation of LGR7 Receptors by Human Relaxin 2 (Michelle L. Halls
Ross A. Bathgate
and Roger J. Summers). 42. Signaling Pathways of the LGR7 and LGR8 Receptors Determined by Reporter Genes (Michelle L. Halls
Ross A. Bathgate
Peter J. Roche
and Roger J. Summers). 43. Relaxin Stimulates cAMP Production in MCF-7 Cells upon Overexpression of Type V Adenylyl Cyclase (Bao T. Nguyen and Carmen W. Dessauer). 44. Pathways Used by Relaxin to Regulate Myometrial Phospholipase C (Miao Zhong
Chun-Ying Ku
and Barbara M. Sanborn). 45. A Novel
Adenylate Cyclase
Signaling Mechanism of Relaxin H2 Action (Alexander Shpakov
Marianna Pertseva
Ludmila Kuznetsova
and Svetlana Plesneva). 46. Relaxin Restores Altered Ileal Spontaneous Contractions in Dystrophic (mdx) Mice (Maria Caterina Baccari
Franco Calamai
Laura Chiappini
Maria Giuliana Vannucchi
and Daniele Bani). 47. Effects of Relaxin on Vascular Smooth Muscle and Endothelial Cells in Normotensive and Hypertensive Rats (Paola Failli
Silvia Nistri
Luca Mazzetti
Laura Chiappini
and Daniele Bani). 48. Relaxin Induces Matrix Metalloproteinase-9 through Activation of Nuclear Factor Kappa B in Human THP-1 Cells (Teh-Yuan Ho and Carol A. Bagnell). 49. Does Human Relaxin-2 Affect Peripheral Blood Mononuclear Cells to Increase Inflammatory Mediators in Pathologic Bone Loss?: P Kristiansson
C Holding
S Hughes
and D Haynes). 50. Demonstration of Upregulated H2 Relaxin mRNA Expression during Neuroendocrine Differentiation of LNCaP Prostate Cancer Cells and Production of Biologically Active Mammalian Recombinant 6 Histidine-Tagged H2 Relaxin (Kevin A. Figueiredo
Jodie B. Palmer
Alice L. Mui
Colleen C. Nelson
and Michael E. Cox). 51. Is Relaxin a Calcium Transporter/Buffer? (Phillip A. Fields). 52. Responses of GPCR135 to Human Gene 3 (H3) Relaxin in CHO-K1 Cells Determined by Microphysiometry (Emma T. Van Der Westhuizen
Patrick M. Sexton
Ross A. D. Bathgate
and Roger J. Summers). Part VA: Clinical Aspects of Relaxin: Pregnancy. 53. Human Decidual Relaxin and Preterm Birth (Gillian D. Bryant-Greenwood
Sandra Y. Yamamoto
Kimberly M. Lowndes
Lisa E. Webster
Simone S. Parg
Aaron Amano
Erika E. Bullesbach
Christian Schwabe
and Lynnae K. Millar). 54. Mechanisms of Relaxin-Mediated Premature Birth (Gerson Weiss and Laura T. Goldsmith). 55. Clinical Use of Relaxin to Facilitate Birth: Reasons for Investigating the Premise (Hyung-Yul Lee
Shuangping Zhao
P A Fields
and O D Sherwood). 56. Relaxin Concentrations in Serum and Urine of Endangered Species: Correlations with Physiologic Events and Use As a Marker of Pregnancy (Bernard G. Steinetz
Janine L. Brown
Terri L. Roth
and Nancy Czekala). Part VB: Clinical Aspects of Relaxin: Connective Tissue. 57. Use of Relaxin in Orthodontics (Dennis R. Stewart
Paul Sherick
Susan Kramer
and Peter Breining). 58. Does Human Relaxin Accelerate Orthodontic Tooth Movement in Rats? (Zi Jun Liu
Gregory J. King
Gao Man Gu
Ja Young Shin
and Dennis R. Stewart). 59. The Use of Relaxin Improves Healing in Injured Muscle (Y Li
S Negishi
M Sakamoto
A Usas
and J Huard). 60. Photonic Monitoring in Real Time of Vascular Endothelial Growth Factor Receptor 2 Gene Expression under Relaxin-Induced Conditions in a Novel Murine Wound Model (Peter L. Ryan
Ramey C. Youngblood
Jane Harvill
and Scott T. Willard). 61. Relaxin of Prostatic Origin Might Be Linked to Perineal Hernia Formation in Dogs (Gert W. Niebauer
Sarina Shibly
Monika Seltenhammer
Armin Pirker
and Sabine Brandt). Part VC: Clinical Aspects of Relaxin: Ischemia/Allergic Response/Cancer. 62. Basic Progress and Future Therapeutic Perspectives of Relaxin in Ischemic Heart Disease (Daniele Bani
Silvia Nistri
Tatiana Bani Sacchi
and Mario Bigazzi). 63. Human Recombinant Relaxin Reduces Heart Injury and Improves Ventricular Performance in a Swine Model of Acute Myocardial Infarction (Avio-Maria Perna
Emanuela Masini
Silvia Nistri
Tatiana Bani Sacchi
Mario Bigazzi
and Daniele Bani). 64. Relaxin as an Additional Protective Substance in Preserving and Reperfusion Solution for Liver Transplantation
Shown in a Model of Isolated Perfused Rat Liver (Markus U. Boehnert
Heidegard Hilbig
and Franz P. Armbruster). 65. Myocardial Relaxin Counteracts Hypertrophy in Hypertensive Rats (Thomas Dschietzig
Cornelia Bartsch
Till Kinkel
Gert Baumann
and Karl Stangl). 66. Relaxin Favors the Morphofunctional Integration between Skeletal Myoblasts and Adult Cardiomyocytes in Coculture (Lucia Formigli
Fabio Francini
Laura Chiappini
Sandra Zecchi-Orlandini
and Daniele Bani). 67. Relaxin Adenylyl Cyclase System of Pregnant Women with Diabetes: Functional Defects in Insulin and Relaxin Adenylyl Cyclase Signaling Systems in Myometrium of Pregnant Women with Type 1 Diabetes (Ludmila Kuznetsova
Svetlana Plesneva
Alexander Shpakov
and Marianna Pertseva). 68. Human Medullary Thyroid Carcinoma: A Source and Potential Target for Relaxin-Like Hormones (T Klonisch
Tarek Mustafa
Joanna Bialek
Yvonne Radestock
Hans-Jürgen Holzhausen
Henning Dralle
Cuong Hoang-Vu
and Sabine Hombach-Klonisch). 69. Relaxin Downregulates the Calcium Binding Protein S100A4 in MDA-MB-231 Human Breast Cancer Cells (Yvonne Radestock
Cuong Hoang-Vu
and Sabine Hombach-Klonisch). 70. Relaxin Does Not Influence the Growth of Human Cervical Adenocarcinoma (HeLa) Cells in Culture (Young Shin Rho and Gyesik Min). 71. Effects of Relaxin in a Model of Rat Adjuvant-Induced Arthritis (Karen Santora
Cordelia Rasa
Denise Visco
Bernard Steinetz
and Carol Bagnell) . Part VI: Physiologic Roles of INSL3. 72. Insulin-Like Factor 3: Where Are We Now? (Richard Ivell
Stefan Hartung
and Ravinder Anand-Ivell). 73. Insulin-Like Factor 3: A Novel Circulating Hormone of Testicular Origin in Humans (Alberto Ferlin and Carlo Foresta). 74. Immunohistochemical Localization of Relaxin-Like Factor/Insulin-Like Peptide-3 in the Bovine Corpus Luteum (Nicole Nichols
Hilary Binta
Phillip A. Fields
Maarten Drost
Shou-Mei Chang
Richard Ivell
and Michael J. Fields). 75. Restricted Expression of LGR8 in Intralaminar Thalamic Nuclei of Rat Brain Suggests a Role in Sensorimotor Systems (Pei-Juan Shen
Ping Fu
Kevin D. Phelan
Daniel J. Scott
Sharon Layfield
Geoffrey W. Tregear
Ross A.D. Bathgate
and Andrew L. Gundlach). 76. Detection
Localization
and Action of the INSL3 Receptor
LGR8
in Rat Kidney (Ping Fu
Pei-Juan Shen
Chong-Xin Zhao
Daniel J. Scott
Chrishan S. Samuel
John D. Wade
Geoffrey W. Tregear
Ross A.D. Bathgate
and Andrew L. Gundlach). Part VII: Evolution of Signaling Systems in Relaxin Family Peptides. 77. Evolution of the Signaling System in Relaxin-Family Peptides (Sheau Yu Teddy Hsu
Jenia Semyonov
Jae-Il Park
and Chia Lin Chang). 78. Evolution of the Relaxin-Like Peptide Family: From Neuropeptide to Reproduction (Tracey N. Wilkinson
Terry P. Speed
Geoffrey W. Tregear
and Ross A.D. Bathgate). 79. Coevolution of the Relaxin-Like Peptides and Their Receptors (Tracey N. Wilkinson
Terence P. Speed
Geoffrey W. Tregear
and Ross A.D. Bathgate)