Andere Kunden interessierten sich auch für
![Hemodialysis Vs Peritoneal dialysis on Lipid profile in CKD patients]( "Hemodialysis Vs Peritoneal dialysis on Lipid profile in CKD patients")
Hemodialysis Vs Peritoneal dialysis on Lipid profile in CKD patients44,99 €![Separation and fractionation techniques]( "Separation and fractionation techniques")
Separation and fractionation techniques26,99 €![Study of the western style diet risk factors on kidney]( "Study of the western style diet risk factors on kidney")
Study of the western style diet risk factors on kidney23,99 €![The Coenzyme Q10 and Antioxidant Vitamins in Renal Failure]( "The Coenzyme Q10 and Antioxidant Vitamins in Renal Failure")
The Coenzyme Q10 and Antioxidant Vitamins in Renal Failure43,99 €![The Fat-Soluble Vitamins]( "The Fat-Soluble Vitamins")
The Fat-Soluble Vitamins42,99 €![History of kidney diseases and stem cells]( "History of kidney diseases and stem cells")
History of kidney diseases and stem cells26,99 €![Kidney Research]( "Kidney Research")
Kidney Research103,99 €
The restoration of normal parathyroid hormone (PTH)
levels for kidney failure patients has to date
proven to be a very challenging clinical problem.
Middle molecular weight toxins such as PTH are
poorly dialyzed, and drug therapies require weeks to
months to lower serum PTH levels. Based on the
characteristic of high specific affinity between
antigen and antibody, a chromatographic column with
packing coated by monoclonal antibody placed in
series with a conventional hemodialyzer has been
designed to reduce PTH levels to normal within one
dialysis session. A mathematical model of the
modified dialysis circuit of the form of a single
delay differential equation, whose approximately
analytical solution was obtained emoplying a Padé
approximation, was developed which reproduces an in
vitro experiment with high accuracy, and indicates
that the immunosorptive column will be efficacious
in lowering PTH levels when scaled up to clinical
scenarios. Process intensification of the modified
dialyzer circuit was also investigated by
functionalizing the lumenal surfaces of the dialyzer
cartridge itself.
levels for kidney failure patients has to date
proven to be a very challenging clinical problem.
Middle molecular weight toxins such as PTH are
poorly dialyzed, and drug therapies require weeks to
months to lower serum PTH levels. Based on the
characteristic of high specific affinity between
antigen and antibody, a chromatographic column with
packing coated by monoclonal antibody placed in
series with a conventional hemodialyzer has been
designed to reduce PTH levels to normal within one
dialysis session. A mathematical model of the
modified dialysis circuit of the form of a single
delay differential equation, whose approximately
analytical solution was obtained emoplying a Padé
approximation, was developed which reproduces an in
vitro experiment with high accuracy, and indicates
that the immunosorptive column will be efficacious
in lowering PTH levels when scaled up to clinical
scenarios. Process intensification of the modified
dialyzer circuit was also investigated by
functionalizing the lumenal surfaces of the dialyzer
cartridge itself.