When Shaul Massry and Herbert Fleisch asked me to write a foreword for this book, I was honored and eagerly looked forward to reading the many chapters. As they came and I skimmed through them, my mind wandered back to the earliest classic contributions in this field in the late 1920s and early 1930s by Albright and his associates, Greenwald and Gross and Adolph, on the homeostatic regulation of inorganic phosphate and the central role of parathyroid hormone (PTH) in this regulation. They clearly showed the exquisite sensitivity of the renal handling of phosphate to varying dietary and…mehr
When Shaul Massry and Herbert Fleisch asked me to write a foreword for this book, I was honored and eagerly looked forward to reading the many chapters. As they came and I skimmed through them, my mind wandered back to the earliest classic contributions in this field in the late 1920s and early 1930s by Albright and his associates, Greenwald and Gross and Adolph, on the homeostatic regulation of inorganic phosphate and the central role of parathyroid hormone (PTH) in this regulation. They clearly showed the exquisite sensitivity of the renal handling of phosphate to varying dietary and parenteral loads and to changes in the level ofPTH. That two outstanding investigators in the field of divalent ion me tabolism should choose to edit a book solely about the renal handling of inorganic phosphate shows how far we have progressed from these early classics to the recent almost exponential increase in the research and publications related to this subject. Despite this increase, I askedmyself, is such a large new monograph, consisting of 13 chapters and 30 distin guished authors, warranted? My reading of these chapters and my learning so much from them convinced me that it is, and my pride was heightened in being asked to write the foreword for this book.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Indices for the Measurement of the Renal Handling of Phosphate.- 1. Introduction.- 2. Glomerular Filtration and Tubular Transport.- 3. Threshold Concentration and Splay for Phosphate.- 4. Indices for the Measurement of the Renal Handling of Phosphate.- 5. References.- 2 Sites of Renal Tubular Reabsorption of Phosphate.- 1. Introduction.- 2. Phosphate Transport between the Glomerulus and the Late Accessible Proximal Convolution of the Superficial Nephron.- 3. Phosphate Transport in the Loop.- 4. Phosphate Transport in the Terminal Nephron.- 5. Conclusions.- 6. References.- 3 Is Phosphate Secreted by the Kidney?.- 1. Introduction.- 2. Phosphate Secretion by Kidneys of Lower Vertebrates.- 3. Is Phosphate Secreted by the Mammalian Kidney?.- 4. Conclusions.- 5. References.- 4 Cellular Mechanisms of Phosphate Transport.- 1. Introduction.- 2. Transmembrane Movement of Phosphate.- 3. Characteristics of Phosphate Transport.- 4. Nonhormonal Factors.- 5. Hormonal Regulation of Phosphate at the Cellular Level.- 6. References.- 5 The Effects of Parathyroid Hormone on Renal Phosphate Handling.- 1. Introduction.- 2. Effects of PTH in Various Segments of the Nephron.- 13. Mode of Action of PTH.- 4. Mechanism of the Phosphaturie Effect of PTH.- 5. References.- 6 Effects of Hormones Other than Parathyroid Hormone on Renal Handling of Phosphate.- 1. Introduction.- 2. Growth Hormone (GH).- 3. Vasopressin (Antidiuretic Hormone; ADH).- 4. Thyroid Hormones (Thyroxine and Triiodothyroine).- 5. Calcitonin (CT).- 6. Glucagon.- 7. Insulin.- 8. Catecholamines.- 9. Glucocorticoids.- 10. Estrogens.- 11. Various Other Hormones.- 12. Tumoral Hyperphosphaturia.- 13. References.- 7 Effects of Vitamin D and Its Metabolites on Renal Handling of Phosphate.- 1. Studies in Humans.- 2. Studies in Animals.-3. Summary.- 4. References.- 8 Effect of Urinary Alkalinization on Renal Phosphate Reabsorption.- 1. Introduction.- 2. Clearance Studies.- 3. Micropuncture Studies.- 4. Microperfusion Studies.- 5. Studies of Luminal Membrane Vesicles.- 6. Theoretical Considerations.- 7. Clinical Implications.- 8. References.- 9 Tubular Adaptation to the Supply and Requirement of Phosphate.- 1. Introduction.- 2. Assessment of the Overall Tubular Capacity to Transport Pi.- 3. Tubular Adaptation to the Dietary Supply of Phosphate.- 4. Tubular Adaptation to the Phosphate Demand of the Organism.- 5. Role of l,25(OH)2D3 in the Tubular Adaptation in Pi Transport.- 6. Localization of the Tubular Adaptation in Pi Transport.- 7. Tubular Adaptation and Acute Phosphaturic Response to PTH.- 8. Mechanism of Tubular Adaptation.- 9. Tubular Adaptation and Disorders of the Renal Pi Transport.- 10. Conclusions.- 11. References.- 10 Role of Extracellular Fluid Volume Expansion and Diuretics in Renal Handling of Phosphate.- 1. Introduction.- 2. Volume Expansion and Phosphate Excretion in the Rat and the Dog.- 3. Volume Expansion and Phosphate Excretion in Humans.- 4. Mechanism of Phosphaturia during Volume Expansion.- 5. Effects of Diuretics on Phosphate Excretion.- 6. References.- 11 Influence of Calcium on Renal Handling of Phosphate.- 1. Introduction.- 2. Physiologic Studies.- 3. Pathologic Studies.- 4. References.- 12 Renal Handling of Phosphate in Renal Failure.- 1. Introduction.- 2. Factors Affecting Renal Handling of Phosphate in Renal Failure.- 3. Role of Serum Phosphorus.- 4. Renal Handling of Phosphate after Renal Transplantation.- 5. References.- 13 Tubular Defects in Phosphate Reabsorption in Clinical Medicine.- 1. Introduction.- 2. Diseases Manifested by a Tubular Phosphate Leak.- 3. Conditions Associated with Increased Renal Tubular Retention of Phosphate.- 4. References.
1 Indices for the Measurement of the Renal Handling of Phosphate.- 1. Introduction.- 2. Glomerular Filtration and Tubular Transport.- 3. Threshold Concentration and Splay for Phosphate.- 4. Indices for the Measurement of the Renal Handling of Phosphate.- 5. References.- 2 Sites of Renal Tubular Reabsorption of Phosphate.- 1. Introduction.- 2. Phosphate Transport between the Glomerulus and the Late Accessible Proximal Convolution of the Superficial Nephron.- 3. Phosphate Transport in the Loop.- 4. Phosphate Transport in the Terminal Nephron.- 5. Conclusions.- 6. References.- 3 Is Phosphate Secreted by the Kidney?.- 1. Introduction.- 2. Phosphate Secretion by Kidneys of Lower Vertebrates.- 3. Is Phosphate Secreted by the Mammalian Kidney?.- 4. Conclusions.- 5. References.- 4 Cellular Mechanisms of Phosphate Transport.- 1. Introduction.- 2. Transmembrane Movement of Phosphate.- 3. Characteristics of Phosphate Transport.- 4. Nonhormonal Factors.- 5. Hormonal Regulation of Phosphate at the Cellular Level.- 6. References.- 5 The Effects of Parathyroid Hormone on Renal Phosphate Handling.- 1. Introduction.- 2. Effects of PTH in Various Segments of the Nephron.- 13. Mode of Action of PTH.- 4. Mechanism of the Phosphaturie Effect of PTH.- 5. References.- 6 Effects of Hormones Other than Parathyroid Hormone on Renal Handling of Phosphate.- 1. Introduction.- 2. Growth Hormone (GH).- 3. Vasopressin (Antidiuretic Hormone; ADH).- 4. Thyroid Hormones (Thyroxine and Triiodothyroine).- 5. Calcitonin (CT).- 6. Glucagon.- 7. Insulin.- 8. Catecholamines.- 9. Glucocorticoids.- 10. Estrogens.- 11. Various Other Hormones.- 12. Tumoral Hyperphosphaturia.- 13. References.- 7 Effects of Vitamin D and Its Metabolites on Renal Handling of Phosphate.- 1. Studies in Humans.- 2. Studies in Animals.-3. Summary.- 4. References.- 8 Effect of Urinary Alkalinization on Renal Phosphate Reabsorption.- 1. Introduction.- 2. Clearance Studies.- 3. Micropuncture Studies.- 4. Microperfusion Studies.- 5. Studies of Luminal Membrane Vesicles.- 6. Theoretical Considerations.- 7. Clinical Implications.- 8. References.- 9 Tubular Adaptation to the Supply and Requirement of Phosphate.- 1. Introduction.- 2. Assessment of the Overall Tubular Capacity to Transport Pi.- 3. Tubular Adaptation to the Dietary Supply of Phosphate.- 4. Tubular Adaptation to the Phosphate Demand of the Organism.- 5. Role of l,25(OH)2D3 in the Tubular Adaptation in Pi Transport.- 6. Localization of the Tubular Adaptation in Pi Transport.- 7. Tubular Adaptation and Acute Phosphaturic Response to PTH.- 8. Mechanism of Tubular Adaptation.- 9. Tubular Adaptation and Disorders of the Renal Pi Transport.- 10. Conclusions.- 11. References.- 10 Role of Extracellular Fluid Volume Expansion and Diuretics in Renal Handling of Phosphate.- 1. Introduction.- 2. Volume Expansion and Phosphate Excretion in the Rat and the Dog.- 3. Volume Expansion and Phosphate Excretion in Humans.- 4. Mechanism of Phosphaturia during Volume Expansion.- 5. Effects of Diuretics on Phosphate Excretion.- 6. References.- 11 Influence of Calcium on Renal Handling of Phosphate.- 1. Introduction.- 2. Physiologic Studies.- 3. Pathologic Studies.- 4. References.- 12 Renal Handling of Phosphate in Renal Failure.- 1. Introduction.- 2. Factors Affecting Renal Handling of Phosphate in Renal Failure.- 3. Role of Serum Phosphorus.- 4. Renal Handling of Phosphate after Renal Transplantation.- 5. References.- 13 Tubular Defects in Phosphate Reabsorption in Clinical Medicine.- 1. Introduction.- 2. Diseases Manifested by a Tubular Phosphate Leak.- 3. Conditions Associated with Increased Renal Tubular Retention of Phosphate.- 4. References.
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