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Sickle-cell anemia is one of the most common diseases encountering the anatomical and physiological characteristics of kidneys. Delay of diagnosis might lead to severe complications resulting in progressive damage to most organs, including the kidneys, liver, lungs, brain, bones, and cardiovascular system, which becomes apparent with increasing age. Renal sonography can serve as early ultrasonic predictors of reno-vascular changes in sickle cell anemia. Thereby these findings can guide clinicians to initiate adequate treatment at an early stage.