Kidneys are dynamic organ and represent the major control system maintaining the body homeostasis. Women and men differ in the pathogenesis, clinical features and prognosis of many diseases.Therefore, kidneys is under the influence of sexual hormones. These facts attracted my attention to study the relation between hormonal mechanisms that involve sex hormones in the pathogenesis of kidney diseases. Thus, the renoprotective effects of phytoestrogen and calcium supplements were evaluated herein.