The originality of this book can be understood in two senses: first by the fact that I expose another conception, without precedent, of the responsibility and I denounce at the same time, like H. Jonas, the little interest shown by the moral philosophy to the aforementioned notion. Finally, I make responsibility the essential element of man's life for more humanity and general ethics in order to establish perpetual peace. My reflection is in the continuity-discontinuity of the previous thoughts. For me, the responsibility must be considered as a psychological disposition that obliges us the unconditional respect of the human in every man (woman) whatever his human condition. Thus, I establish a law named categorical imperative of responsibility: always act in such a way that the maxim of your action unconditionally respects the human in every man (woman) whatever his social status. In this book, therefore, I evoke the ethics of Ubuntu. I emphasize that by inserting the imperativeof my new conception of responsibility into the ethics of Ubuntu, they (Responsibility and Ubuntu) would serve, no doubt, as prolegomena to the general ethics.