I realize that this book will create a easy way of understanding about the first line drug in treatment of hyperlipidemia- Statin. I feel obligued to share my knowledge, analyses and conclusions. Hopefully this account will raise the level of awareness before using the drug especially cardiovascular drugs. This book contains two chapter. Chapter 1 is a general information about the statin. Chapter 2 presents the toxicites produced by the statin. Finally this book conclude that though we know the negative aspects of this Medicine, we pushed in the way of using this kind of drugs at last due to unavailability of other drug with zero toxicites. In short I remember the word of Napoleon Bonaparte, French general- Medicine is a collection of uncertain prescriptions, the results of which taken collectively are more fatal than useful to mankind.