The recent rebellion of the Seleka rebels in Central African Republic (CAR) is one that left destruction and displacement of thousands of refugees from CAR to Cameroon. Among those who fled into Cameroon as a consequence, were women and children and as a result, became refugees. They entered Cameroon through its eastern borders. In the process of protecting women and children through implementing international humanitarian law rules, various visible challenges were encountered not only by caregivers, supervision on field but also refugees. The International humanitarian law as well as the Cameroonian government have taken legal measures to protect these vulnerable groups. Protection of vulnerable women and children in the wake of insurgency such as that of the Seleka rebels of CAR remains a major preoccupation to the international community as a whole. An increase in personnel both by the government and NGOs, could provide refugees with better healthcare systems, social welfare and other relevant infrastructures needed to cater for their overall needs.