Tuberculosis is a chronic or acute bacterial infection, caused by Mycobacterium tuberculosis. Most of the people in the world has been infected with with TB causing bacteria. Pulmonary tuberculosis is the most common form of TB. Multidrug-resistance is a major public health problem that threatens progress made in TB care and control worldwide. Several risk factors play an important role in the development of MDR-TB. The major risk factors include irregularity in taking medicine, large family size, farming as occupation, past history of TB and bovine at home which were statistically significant while alcoholism, smoking, family income, education were not associated with MDR-TB.