Besides the remarkable capabilities nanotechnologies promise, there are also substantial uncertainties regarding their possible hazards. The dissertation evaluates the regulation of nanotechnologies in German and (where applicable) in European law and assesses the balance of opportunities and risks within their relevant underlying law. In order to propose a framework for the legal management of potential risks from nanomaterials, a comparative reflexion incorporating similar regulative contexts was integrated. In this respect, the thesis gives an orientation how the uncertain hazards in the field of nanotechnologies can be managed within their users and producers.