Provides the concepts and tools for developing drug-like small molecules that selectively target RNA rather than proteins, including the first successful examples from the development pipeline of big pharma.
Provides the concepts and tools for developing drug-like small molecules that selectively target RNA rather than proteins, including the first successful examples from the development pipeline of big pharma.
John Schneekloth, Jr., PhD (Jay), obtained his PhD from the chemistry department of Yale University. Following postdoctoral work at Princeton, Dr. Schneekloth joined the NCI, where his research involves using synthetic chemistry and high throughput chemical biology approaches to develop chemical probes of RNA, with a particular emphasis on targeting RNA with druglike small molecules. Martin Pettersson, PhD, obtained his PhD in Organic Chemistry from the University of Texas at Austin. He is a medical chemistry / drug discovery leader with over 20 years of industrial experience, mainly with Pfizer (co-inventor of Paxlovid). He has then continued as Senior Director of Neuroscience/Pain, Chemistry, at Grünenthal Boston Innovation Hub, and most recently as VP of Drug Discovery at Promedigen in South Korea.
Inhaltsangabe
1. Introduction 2. RNA Structure Probing, Dynamics, and Folding 3. High Resolution Structures of RNA 4. Screening and Lead Generation Techniques for RNA Binders 5. Chemical Matter that Binds RNA 6. MicroRNAs as Targets for Small Molecule Binders 7. Pre-mRNA Splicing Modulation 8. Prospects for Riboswitches in Drug Development 9. Small Molecules That Degrade RNA 10. Approaches to the Identification of Molecules Altering Programmed Ribosomal Frameshifting in Viruses 11. RNA-Protein Interactions: A New Approach for Drugging RNA Biology 12. Drugging the Epitranscriptome 13. Outlook. A Perspective on RNA: The Next Frontier for Small Molecule Therapeutics
1. Introduction 2. RNA Structure Probing, Dynamics, and Folding 3. High Resolution Structures of RNA 4. Screening and Lead Generation Techniques for RNA Binders 5. Chemical Matter that Binds RNA 6. MicroRNAs as Targets for Small Molecule Binders 7. Pre-mRNA Splicing Modulation 8. Prospects for Riboswitches in Drug Development 9. Small Molecules That Degrade RNA 10. Approaches to the Identification of Molecules Altering Programmed Ribosomal Frameshifting in Viruses 11. RNA-Protein Interactions: A New Approach for Drugging RNA Biology 12. Drugging the Epitranscriptome 13. Outlook. A Perspective on RNA: The Next Frontier for Small Molecule Therapeutics
Es gelten unsere Allgemeinen Geschäftsbedingungen: www.buecher.de/agb
Impressum
www.buecher.de ist ein Internetauftritt der buecher.de internetstores GmbH
Geschäftsführung: Monica Sawhney | Roland Kölbl | Günter Hilger
Sitz der Gesellschaft: Batheyer Straße 115 - 117, 58099 Hagen
Postanschrift: Bürgermeister-Wegele-Str. 12, 86167 Augsburg
Amtsgericht Hagen HRB 13257
Steuernummer: 321/5800/1497
USt-IdNr: DE450055826
