Gunter Meister

RNA Biology

• Broschiertes Buch

Produktbeschreibung

Das erste moderne Lehrbuch der RNA-Biologie auf fortgeschrittenem Niveau fängt die Faszination dieser aufstrebenden Disziplin ein. Alle Aspekte von Ribozymen über RNA-Interferenz bis zur RNomik werden ausführlich diskutiert und in den geeigneten Kontext gestellt.

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Produktdetails

• Verlag: Wiley-VCH
• Artikelnr. des Verlages: 1132278 000
• 1. Auflage
• Seitenzahl: 380
• Erscheinungstermin: 6. April 2011
• Englisch
• Abmessung: 244mm x 170mm x 21mm
• Gewicht: 740g
• ISBN-13: 9783527322787
• ISBN-10: 3527322787
• Artikelnr.: 29963603

Autorenporträt

Gunter Meister is the head of the department of biochemistry I of the University of Regensburg, Germany. He obtained his PhD degree from the University of Munich and the Max-Planck-Institute of Biochemistry, working on RNA-protein complexes. Thereafter, he joined the group of Tom Tuschl at the Rockefeller University in New York (USA), where he worked on RNA interference and small non-coding RNAs. After his postdoctoral time in New York, he went back to the Max-Planck-Institute of Biochemistry as independent group leader and head of the ?RNA Biology? group. Gunter Meister has received an EMBO long-term fellowship as well as an Emmy Noether fellowship from the Deutsche Forschungsgemeinschaft. He was awarded the Max-Planck junior research award as well as the research award of the Engelhorn foundation.

Inhaltsangabe

Preface PART I: mRNA Biology INTRODUCTION RNA Building Blocks RNA Folding
The RNA World Hypothesis Functions of RNA Protein Classes that are Required
for RNA Function TRANSCRIPTION OF PRE-mRNAs Structure and Organization of
Protein Coding Genes Transcription of mRNAs by RNA Polymerase II
Transcriptional Termination of Pre-mRNAs Transcription is Coupled to Other
mRNA Maturation Steps Summary CAPPING OF THE PRE-mRNA 5' END m7 G-cap
Structure mRNA Capping Enzymes 5' Capping is Coupled to Transcription 5'
Cap Binding Proteins Summary 3' END PROCESSING OF PRE-mRNAs Polyadenylation
Signals Proteins Involved in 3' End Processing of Pre-mRNAs 3' End
Processing is Tightly Linked to Transcriptional Termination Alternative
Polyadenylation Cytoplasmic Polyadenylation 3' End Processing of Histone
mRNAs Summary SPLICING OF EUKARYOTIC PRE-mRNAS Group I, II and III Introns
The Mechanism of pre-mRNA Splicing The Spliceosome The U12-Dependent Minor
Spliceosome Coupling of Splicing with Transcription and 5' Capping
Alternative Splicing and the Complexity of Genomes Summary Questions mRNA
EXPORT FROM THE NUCLEOUS TO THE CYTOPLASM Nuclear Import and Nuclear Export
mRNA Export Receptors Adaptors the Bridge mRNAs with Export Receptors
Mechanism of mRNA Export Coupling of mRNP Export to Other Steps of mRNA
Maturation Summary Questions TRANSLATION Amino Acids, mRNAs, tRNAs THe
Ribosome The Mechanisms of Translation Translational Regulation Coupling
Translation with Other mRNA Maturation and Quality Control Steps Summary
Questions DEADENYLATION OF mRNA Deadenylating Enzymes Summary Questions
mRNA DECAPPING Decapping Enzymes are the Core of the mRNA Decapping
Machinery Scavenger Decapping Enzyme DcpS Regulation of mRNA Decapping
Intracellular Localization of mRNA Decapping Summary Questions mRNA DECAY
PATHWAYS Deadenylation-Dependent mRNA Decay Deadenylation-Independent mRNA
Decay Endoribonuclease-Mediated mRNA Decay Regulation of mRNA Decay RNA
Degradation in Bacteria Summary Questions mRNA QUALITY CONTROL Nuclear mRNA
Quality Control Mechanisms Nonsense-Mediated mRNA Decay (NMD) Other nRNA
Quality Control Pathways Summary Questions PART II: Non-Coding RNA Biology
RIBOSOMAL RNAS AND THE BIOGENESIS OF RIBOSOMES Genomic Organization of
Ribosomal RNA Genes Transcription of Ribosomal RNA Genes Maturation of
rRNAs Nuclear Export of Ribosomal Subunits Modification, Structure and
Fucntion of rRNAs Summary Questions TRANSFER RNAS Genomic Organization and
Transcription of tRNA Genes Processing to Mature tRNAs tRNA Modifications
Nuclear Export of tRNAs Tertiary Structure of tRNAs Summary THE 7SL RNA AND
THE SIGNAL RECOGNITION PARTICLE Architecture of the SRP SRP-Mediated
Protein Translocation Summary REGULATION OF TRANSCRIPTION: THE 7SK SMALL
NUCLEAR RNA Architecture of the 7SK snRNA The 7SK snRNP Functions as
Transcriptional Regulator Other Small Non-Coding RNAs that Interfere with
Transcription Summary SMALL NUCLEOLAR RNAS Genomic Organization and snoRNA
Transcription Box H/ACA snoRNAs Box C/D snoRNAs Maturation of Functional
snoRNPs Orphan snoRNAs The Telomerase RNP Summary SPLICEOSOMAL SMALL
NUCLEAR RNAS Transcription and Maturation of Spliceosomal snRNAs The
Structure of UsnRNPs Assembly of Spliceosomal snRNPs Summary Questions
SMALL NON-CODING RNAS AND THE MECHANISM OF GENE SILENCING Short Interfering
RNAs and the Mechanism of RNA Interference Dicer RNA-Dependent RNA
Polymerases Argonaute Proteins microRNAs and the Regulation of Gene
Expression PiRNAs and the Regulation of Mobile Genetic Elements in the Germ
Line Small RNAs with Functions in Chromatin Regulation The CRISPR System -
A Bacterial and Archaeal Defense Mechanism Summary LONG NON-CODING RNAS The
XIST Non-Coding RNA and X Chromosome Inactivation Dosage Compensation n
Flies Non-Coding RNAs and the Regulation of Imprinting The Regulation of
HOX Genes by Long Non-Coding RNAs Long Non-Coding RNAs are Common in
Complex Genomes Summary RNA EDITING RNA Editing by U Insertions or
Deletions RNA Editing by Base Modification Summary RIBOZYMES - CATALYTIC
RNA MOLECULES Identification of Catalytic RNAs Mechanisms and Secondary
Structures of Different Ribozymes Summary RIBOSWITCHES AND RNA SENSORS
Mechanisms of Riboswitch Function Riboswitch Structures RNA Thermometers
Summary RNOMICS "Omics" Approaches Experimental RNA Profiling Strategies
RNA Biology and the Complexity of Genomes Summary APPENDIX Answers to
Questions