RNA-dependent RNA Polymerase
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High Quality Content by WIKIPEDIA articles! RNA-dependent RNA polymerase (RdRP), (RDR), or RNA replicase, is an enzyme that catalyzes the replication of RNA from an RNA template. This is in contrast to a typical RNA polymerase, which catalyzes the transcription of RNA from a DNA template. Viral RdRPs were discovered in the early 1960s from studies on mengovirus and polio virus when it was observed that these viruses were not sensitive to actinomycin D, a drug that inhibits cellular DNA directed RNA synthesis.This lack of sensitivity suggested that there was a virus specific enzyme that could copy RNA from an RNA template and not from a DNA template.…mehr

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High Quality Content by WIKIPEDIA articles! RNA-dependent RNA polymerase (RdRP), (RDR), or RNA replicase, is an enzyme that catalyzes the replication of RNA from an RNA template. This is in contrast to a typical RNA polymerase, which catalyzes the transcription of RNA from a DNA template. Viral RdRPs were discovered in the early 1960s from studies on mengovirus and polio virus when it was observed that these viruses were not sensitive to actinomycin D, a drug that inhibits cellular DNA directed RNA synthesis.This lack of sensitivity suggested that there was a virus specific enzyme that could copy RNA from an RNA template and not from a DNA template.