Rodrigo de Castro Osorio, (Valladolid March 5 of 1523 - 1600 Seville) was Cardinal-Bishop of Zamora (1574 1578) and Diocese of Cuenca (1578 1581), Archbishop of Seville, (1581 1600), a member of the Council of State of Spain and the Supreme Council of the Spanish Inquisition for the reign of Philip II of Spain. Great-uncle of Pedro Fernández de Castro y Andrade, Conde de Lemos. He was closely linked to the city of Monforte de Lemos in Galicia, where he was the founder of the College of Our Lady of Antigua.