Razvitie stenoziruyushchikh porazheniy arteriy tesno svyazano s zashchitnoy reaktsiey organizma na proiskhodyashchiy v stenke sosuda vospalitel'nyy protsess, kogda popytka lokalizatsii ochaga vospaleniya privodit k chrezmernomu fibroproliferativnomu kletochnomu otvetu, vyzyvayushchemu suzhenie vnutrennego prosveta arterii. Posledovatel'nost' biologicheskikh sobytiy v stenke arterii v protsesse takogo izbytochnogo remonta vklyuchaet nakoplenie lipidov, aktivatsiyu i degranulyatsiyu trombotsitov, proniknovenie v subendotelial'noe prostranstvo kletok vospaleniya, migratsiyu i proliferatsiyu sinteziruyushchikh ekstratsellyulyarnyy matriks stromal'nykh kletok. V razvitie stenoziruyushchikh protsessov v stenkakh arteriy vovlekayutsya razlichnye kletochnye populyatsii, v tom chisle kletki gematogennogo proiskhozhdeniya. Rezul'taty mnogikh nauchnykh issledovaniy dokazyvayut vazhnost' i mnogogrannost' uchastiya kletok krovi v protsessakh stenozirovaniya arteriy. Nastoyashchaya rabota posvyashchena osveshcheniyu razlichnykh aspektov uchastiya kletok gematogennogo proiskhozhdeniya (trombotsitov, kletok vospaleniya i kletok-predshestvennikov razlichnykh liniy differentsirovki) v patogeneze ateroskleroza, stenoza arteriy i restenoza posle implantatsii stentov.