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Gallstone disease is common all over the world. Cholecystectomy is the treatment of choice for symptomatic gall stones. The aim of this work is to evaluate the role ERCP in management of post-cholecystectomy (open-laparoscopic) biliary complications. These prospective study was conducted in Al-Azhar University Hospitals (in a period from 9/2015 -9/2018) evaluate ERCP in management of post-cholecystectomy biliary complications in about 30 cases who were subjected to cholecystectomy and suffered from biliary tree related complications such as external bile leak, localized bile collection, bile peritonitis, or obstructive jaundice, missed stone.