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Health information system in Pakistan is poorly designed and collecting incomplete, inaccurate, untimely and unrelated data, which does not help in decision making for planning and management purposes. Study was a retrospective descriptive based on the data recorded in District HMIS cell and monthly reports of 34 health facilities on priority disease and other related health events and also observes the various steps, components and the application of HMIS in disease reporting. Data was collected through a format of questionnaire and was processed by hand sorting techniques, calculator and statistical program for social sciences (SPSS) version 16. The findings of the result showed that only 34 health facilities out of 72 are reporting and 38 not reporting. In 77% of health facilities had trained personnel in HMIS reporting, hence 62% reports received were found to be accurate. 62% reports were not submitted in time. About 85% reports were analyzed and interpret and 79% of the cases action was taken. Improper maintaining record, lack of interest and cooperation of doctors, inadequate staffing, poor supervision, were the factors affecting reporting.