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Inflammation triggers pathological warnings in the human body including infection, autoimmune disease, metabolic syndrome and cancer. In this book the authors determine the molecular effect of the pro-inflammatory cytokine IL-6 in breast cancer. The authors describe several mechanisms by which IL-6 exposure can foster tumor progression via the expansion of a specific population of cancer cells, called cancer stem cells (CSCs). These cells represent a small fraction of each tumor and dictate tumor progression toward a pro-metastatic phenotype. The authors unravel a unique mechanism by means…mehr

Produktbeschreibung
Inflammation triggers pathological warnings in the human body including infection, autoimmune disease, metabolic syndrome and cancer. In this book the authors determine the molecular effect of the pro-inflammatory cytokine IL-6 in breast cancer. The authors describe several mechanisms by which IL-6 exposure can foster tumor progression via the expansion of a specific population of cancer cells, called cancer stem cells (CSCs). These cells represent a small fraction of each tumor and dictate tumor progression toward a pro-metastatic phenotype. The authors unravel a unique mechanism by means IL-6 mediated the conversion of non-stem cells into CSCs capable of surviving in tumor-stoma niches and hypoxic niches. Inflammation, hypoxia, CSCs and breast cancer share the up-regulation of IL-6 as a common mediator of malignancy.
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Autorenporträt
Dr. Pasquale Sansone is currently an Instructor of Molecular Biology in Pediatrics at Weill Cornell Medical Center (WCMC, NYC) and a Research Associate at Memorial Sloan-Kettering Cancer Center (MSKCC, NYC). Dr. Sansone is an established scientist in the field of (breast) cancer stem cells, tumor microenvironment, metastasis and therapy resistance.