Cardiovascular complications such as hypertension, atherosclerosis etc., are growing day by day and prevalence is even more in affluant society. Atherosclerosis is one of the most common cause of death all over the world. The importance of leukotrienes receptors in atherosclerosis are widely accepted. Here this book demonstrated that the montelukast, a cystenyl leukotirenes receptor antagonist inhibit the progression of atherosclerosis and reduces atherosclerotic index in rats. This book may useful to understand about importance of leukotriene receptors in atherosclerosis.