The growth of the craniofacial region and orthodontic and dentofacial orthopedic procedures are thought to be correlated with the shape and function of the masticatory muscles. The orthodontist can identify the functional goals of the orthodontic treatment by having a understanding of the relationship between various malocclusions and mandibular dysfunction. This evaluation must take into account the frequency of dysfunction and the broad etiological causes that are to blame. This review discusses how orofacial muscles contribute to the formation of malocclusions and dentoskeletal alterations, which is important for the diagnosis and formulation of treatment plans in orthodontic practice.