The purpose of this book is to highlight the role of PET/CT in evaluation of post-therapeutic hepatocellular carcinoma, hence guiding the clinician to proper management strategy. Our study included 35 patients (32 male and 3 female). All patients had history of local treatment of HCC; most of the cases were treated with TACE or RFA, TACE was the main non-operative therapy for large or advanced intrahepatic HCC, while RFA was the main non-operative therapy for small HCCs. The data in our study showed that PET/CT as a metabolic imaging modality could evaluate therapeutic effect and prognostic value in patients with post therapeutic HCC and also can perform full body scanning in a single session and sensitively detect both primary and metastatic tumors.