Role of Rosuvastatin in Segmentalbone Healing - Konyak, Manloi;Guha, Shyamal Kanti
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Fracture healing is a multistage well-orchestrated repair process initiated in response to injury, resulting in the repair and restoration of function nearer to normalcy. Healing mechanism is biologically controlled by an interaction of various hormones, cytokines, extra cellular matrix and different growth factors. Besides these statins, bisphosphonates are also considered under recent investigations. In the recent past, molecules with anti-resorptive and anabolic or even combined activities have been identified and their role in enhancing bone healing mechanism is still under investigation.…mehr

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Produktbeschreibung
Fracture healing is a multistage well-orchestrated repair process initiated in response to injury, resulting in the repair and restoration of function nearer to normalcy. Healing mechanism is biologically controlled by an interaction of various hormones, cytokines, extra cellular matrix and different growth factors. Besides these statins, bisphosphonates are also considered under recent investigations. In the recent past, molecules with anti-resorptive and anabolic or even combined activities have been identified and their role in enhancing bone healing mechanism is still under investigation. One of such new molecule is Rosuvastatin, a hydrophilic statin that has shown promising results in augmentation of fracture healing mechanism.The statin molecule used in the present study augmented bone healing and remodeling process, thus conformed their biological osteoinductive property. As a consequence of osteoinnductive and osteogenic properties, Rosuvastatin can be recommended in postmenopausal osteoporosis treatment in human and bone defects in veterinary clinical and medical practice in near future.
Autorenporträt
Dr. Manloi Konyak finished his B.V.Sc&A.H in 2010 from Central Agricultural University in Aizawl,India and completed his MVSc from West Bengal University of Animal and Fishery Sciences in Veterinary Surgery and Radiology in the year of 2012.At present he is working under Animal Husbandry Department,Government of Nagaland,India as veterinary Doctor.