Orthodontists as oral health care providers always strive to provide best quality treatment to their patients and alleviate their dental and facial concerns. Orthodontic materials as well as procedures, right from impression making to placement of appliances and beyond are directly affected by saliva. Hence, comprehensive knowledge of the physiology of salivary secretion along with the various methods of isolation available to the orthodontist is essential so that most optimal treatment can be rendered to the patients.