Stem cells represent natural units of embryonic development and tissue regeneration. Stem cells are pluripotent cells which have the natural capacity to divide into multiple cells with controlled and marked hyperplasia. It plays a pivotal role in the development of tooth which is regulated by the process of regenerative endodontics The potential of stem cells to treat devastating diseases has been introduced as one of the greatest medical breakthroughs of all time. Stem cells have more roles to play in medicine and dentistry. The complete restoration of the physiologic, structural & mechanical integrity of the native tissue structure is fascinating fact and it's a way far to reach the hands of mankind. Advances in adult stem cell biology have provided a great deal of impetus for the biomedical community to translate these findings into clinical application.