Gyanendra Kumar Sonkar

Role of various markers in rejection and survival of renal transplant

Markers influencing the rejection and long term survival in patients with renal graft

• Broschiertes Buch

Produktbeschreibung

Long term survival of renal graft is still a challenge in this era of better immunosuppression.This study highlighted the role of immunological & biochemical markers involved in transplant rejection.Cell mediated immunity is the main cause of rejection in both ACR and CAN while in CAN humoral immunity is also involved along with cellular immunity. Study supports that histopathology is still a gold standard test for differentiation of rejection.SCr is still a cheap & sensitive serological marker to diagnose rejection & is equally good as 2m.Blood cholesterol should be kept on lower side.Screening for infections such as TB,CMV & S.paratyphi should be carried out for long term survival.HLA plays crucial role in survival. Study supported that HLA A33 has protective role while HLA A23,B37,DR1,DR3,DR8,DR53 have predisposing effect for renal failure in transplant recipient.Graft survival is better for 2 HLA antigens mismatch between donor and recipient than only 5/4/3 HLA antigen mismatch between donor & recipient.Study also throws light that male donor & male recipient have better graft survival than female recipient or male recipient with female donor.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 296
• Erscheinungstermin: 29. Oktober 2010
• Englisch
• Abmessung: 220mm x 150mm x 18mm
• Gewicht: 400g
• ISBN-13: 9783843356329
• ISBN-10: 3843356327
• Artikelnr.: 32301335

Autorenporträt

Awarded PhD in 2009.Working as Assistant Professor.Field of Specialization is Transplant Immunology,Autoimmunity & Clinical Biochemistry.Has eight international & two national publications. Recieved UCB-ICAAI Young Scientist Award at ICAAICON in year 2008. Co editor of book ¿Manual of Immunopathological Techniques¿ (about to complete).