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The most effective way in the practice of endodontics is to disinfect and obturate the canals as efficiently and effectively as possible with an inert, dimensionally stable and biologically compatible material. The important constituent of root filling includes a sealer and a solid core material. Gutta-percha is universally accepted as the "Gold standard" for the obturating materials. The sealer has as much or more importance than the core material in providing a successful clinical outcome. Various types of sealers are available like resin sealers, Mineral Trioxide aggregate sealer, Bio-ceramic containing sealers, ZOE sealers, Glass ionomer containing sealer, calcium hydroxide containing sealer etc. Bio ceramic materials containing calcium phosphate, enhances the setting properties of bio ceramics, thereby improving sealer-to-root dentin bonding. The creation of most desired 'Three dimensional obturation', nonetheless seems to get shackled by the general lack of chemical union between the polyisoprene component of gutta-percha cone and the components of endodontic sealer.