RP-HPLC Method Development and Validation for Palbociclib and Letrozole - Dange, Yuvraj;Salunkhe, Vijay;Dange, Vidya
39,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 1-2 Wochen
payback
20 °P sammeln
  • Broschiertes Buch

Current aim is to develop a simple, rapid, accurate, economic, precise stability indicating assay method for the simultaneous estimation of Palbociclib and Letrozole in pure drug and dosage form. For these purpose choices of a common solvent was essential so various solvent ranges including methanol, ethanol, acetonitrile,and phosphate buffer and various concentrations ranges of various buffers were analyzed. Few methods have been reported on above drugs by using water as common solvent which is the cheapest; therefore finally the common solvent for the above drugs was chosen as sodium…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
Current aim is to develop a simple, rapid, accurate, economic, precise stability indicating assay method for the simultaneous estimation of Palbociclib and Letrozole in pure drug and dosage form. For these purpose choices of a common solvent was essential so various solvent ranges including methanol, ethanol, acetonitrile,and phosphate buffer and various concentrations ranges of various buffers were analyzed. Few methods have been reported on above drugs by using water as common solvent which is the cheapest; therefore finally the common solvent for the above drugs was chosen as sodium Dihydrogen phosphate pH 5.5 (0.05 mm) which is more cheaper than any organic solvent. Palbociclib and Letrozole show maximum absorbance at 220 and 240 nm respectively. Both drugs obey Beer Lambert's law in the concentration range of 2-10 mig/ml and 40-140 mig/ml for Palbociclib and Letrozole respectively.The RP-HPLC method was developed using Intersil ODS-C8, (4.6mm x 250mm; 5mim) column, at ambient temperature using mobile phase Methanol: Acetonitrile: 0.05mM sodium dihydrogen phosphate buffer (pH adjusted to 5.5 with NaOH) in10:10:80 v/v proportion found to give sharp, well defined peaks.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Autorenporträt
Mr. Yuvraj Dilip Dange, M.Pharm, Assistant Professor at Annasaheb Dange College of pharmacy, Ashta Tal-Walwa, Dist- Sangli.Education: PhD (perusing) Shivaji University Kolhapur.B.Pharm & M.Pharm from Rajarambapu College of pharmacy, Kasegaon. He has 4 years  experience in teaching field and 15 papers in national and international reputed journals