RP-HPLC Method for the Determination of Sertraline - Kalyani, L.;Lakshmana Rao, A.
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A simple, accurate and precise RP-HPLC method has been developed and validated for the determination of Sertraline in bulk and tablet dosage forms. Separation of the drug was achieved on a Symmetry C18 column (150mm x 4.6mm, 5µm) using a mobile phase consisting of ammonium acetate buffer and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.8ml/min at ambient temperature. The quantification was achieved with UV detection at 273nm. The linearity was observed over the concentration range of 50-250µg/ml with a correlation coefficient of 0.999. The accuracy of the proposed method was…mehr

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Produktbeschreibung
A simple, accurate and precise RP-HPLC method has been developed and validated for the determination of Sertraline in bulk and tablet dosage forms. Separation of the drug was achieved on a Symmetry C18 column (150mm x 4.6mm, 5µm) using a mobile phase consisting of ammonium acetate buffer and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.8ml/min at ambient temperature. The quantification was achieved with UV detection at 273nm. The linearity was observed over the concentration range of 50-250µg/ml with a correlation coefficient of 0.999. The accuracy of the proposed method was determined by recovery studies and found to be 98-100.3% of Sertraline. The proposed method can be employed for routine quality control analysis of Sertraline in tablet dosage forms.
Autorenporträt
Working as Assistant Professor at V.V. Institute of Pharmaceutical Sciences, Gudlavalleru, A.P. She published 10 research papers in various International and National Journals; attended 12 Seminars, Conferences and Workshops and received many prizes. Her area of research includes Development of New Analytical Methods by using HPLC, HPTLC and LC-MS.