H. Gerhard Vogel / Franz Jacob Hock / Jochen Maas / Dieter Mayer (eds.)
Safety and Pharmacokinetic Assays / Drug Discovery and Evaluation
Herausgegeben:Vogel, Hans G.; Vogel, Hans G., Herausgegeben:Hock, Franz J.; Maas, Jochen
Versandkostenfrei innerhalb Deutschlands
498,21 €
inkl. MwSt.
Versandkostenfrei*
Liefertermin unbestimmt
Melden Sie sich
hier
hier
für den Produktalarm an, um über die Verfügbarkeit des Produkts informiert zu werden.
0 °P sammeln
H. Gerhard Vogel / Franz Jacob Hock / Jochen Maas / Dieter Mayer (eds.)
Safety and Pharmacokinetic Assays / Drug Discovery and Evaluation
Herausgegeben:Vogel, Hans G.; Vogel, Hans G., Herausgegeben:Hock, Franz J.; Maas, Jochen
- Audio CD mit DVD
This book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs. The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process. In particular, the book will be of use for government institutions and committees…mehr
Andere Kunden interessierten sich auch für
- Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays1.244,99 €
- Hans Georg Vogel / Jochen Maas / Alexander Gebauer (Hrsg.)Drug Discovery and Evaluation: Methods in Clinical Pharmacology402,99 €
- David Z. D'Argenio (Hrsg.)Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis156,99 €
- Siamak C. KhojastehDrug Metabolism and Pharmacokinetics Quick Guide81,99 €
- Rajesh Krishna (Hrsg.)Applications of Pharmacokinetic Principles in Drug Development83,99 €
- Cell-Based Assays Using iPSCs for Drug Development and Testing130,99 €
- Antimicrobial Drug Resistance226,99 €
-
-
-
This book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.
The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.
In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide.
Bei diesem Produkt handelt es sich um ein Bundle, bestehend aus einem Buch und einem digitalen Mehrwert.
Deshalb wird dieses Produkt auf der Rechnung mit 19% MwSt ausgewiesen.
The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.
In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide.
Bei diesem Produkt handelt es sich um ein Bundle, bestehend aus einem Buch und einem digitalen Mehrwert.
Deshalb wird dieses Produkt auf der Rechnung mit 19% MwSt ausgewiesen.
Produktdetails
- Produktdetails
- Springer Reference
- Verlag: Springer, Berlin
- Seitenzahl: 889
- Erscheinungstermin: 23. Mai 2006
- Englisch
- Abmessung: 270mm
- ISBN-13: 9783540334422
- ISBN-10: 3540334424
- Artikelnr.: 20853776
- Herstellerkennzeichnung Die Herstellerinformationen sind derzeit nicht verfügbar.
- Springer Reference
- Verlag: Springer, Berlin
- Seitenzahl: 889
- Erscheinungstermin: 23. Mai 2006
- Englisch
- Abmessung: 270mm
- ISBN-13: 9783540334422
- ISBN-10: 3540334424
- Artikelnr.: 20853776
- Herstellerkennzeichnung Die Herstellerinformationen sind derzeit nicht verfügbar.
Hans G. Vogel, Aalen, Germany / Franz G. Hock, Dieburg, Germany / Dieter Mayer, Idstein, Germany / Jochen Maas, Aventis Pharma, Frankfurt, Germany
General Introduction: Section I Safety Pharmacology: Introduction for Section I Safety Pharmacology.- Status of Safety Pharmacology and present Guidelines.- Central Nervous System Safety Pharmacology Studies.- Methods in Cardiovascular Safety Pharmacology.- Safety Pharmacology for Renal System Drugs.- Respiratory Function Assays in Safety Pharmacology.- Safety Tests in Metabolism Pharmacology.- Safety Pharmacology in Peripheral Nervous System Drugs.- Safety Pharmacology for Intravenous and Inhalation Anesthetics.- Side effects of central analgesic drugs.- Safety Pharmacology of Anti-inflammatory drugs.- Safety Pharmacology of Drugs with Osteoarthritis-related activity.- Safety Pharmacology of Blood Constituents.- Safety Assessment of Drugs Used in Ophthalmology.- Safety Assays in Endocrine Pharmacology.- Safety Assays in Skin Pharmacology.- Safety Pharmacology in Biologics.- Magnetic Resonance Imaging in Pharmaceutical Safety Assessment.- Perspectives of Safety Pharmacology, Ongoing Initiatives and Activities, Pharmaceuticals in the Environment.- Section II Safety Pharmacokinetics: Introduction.- Absorption-ex vivo tests.- Absorption-in vitro tests-cell based.- Absorption-in vitro tests-non cell based.- Absorption-in vivo tests (radiolabeled).- Bioanalytical assays-GC.- Bioanalytical assays-LC-MS/MS.- Bioanalytical assays-RIA/ELISA.- Bioanalytical assays-Toxicokinetics.- Clinical studies-typical designs.- Distribution-across barriers.- Distribution-in vitro tests-protein binding.- Distribution-in vivo-other methods.- Distribution-in vivo-perfused organs.- Distribution-in vivo-QWBA.- Drug-drug interaction-enzyme induction.- Drug-drug interaction-enzyme inhibition.- In-silico ADME Modeling.- Metabolism-enzyme mapping.- Metabolism-in vitro stability/profiling.- Metabolism-in vivo profiling.- Pharmacogenomics in DME.- Physicochemical properties.- Population kinetics.- Typical PK/PD approaches.- Section III Safety toxicology: Introduction.- International Guidelines.- General toxicity (acute, subchronic, chronic, carcinogenicity).- In silico methods.- Alternative methods for carcinogenicity testing.- Drug Addiction in monkeys.- Genotoxicity.- Pathology.- Reproductive Toxicology.- Toxicogenomics.- Toxicoproteomics
From the contents: General Introduction: Safety Pharmacology.- Safety Pharmacokinetics.- Safety Toxicology.
From the contents: General Introduction: Safety Pharmacology.- Safety Pharmacokinetics.- Safety Toxicology.
General Introduction: Section I Safety Pharmacology: Introduction for Section I Safety Pharmacology.- Status of Safety Pharmacology and present Guidelines.- Central Nervous System Safety Pharmacology Studies.- Methods in Cardiovascular Safety Pharmacology.- Safety Pharmacology for Renal System Drugs.- Respiratory Function Assays in Safety Pharmacology.- Safety Tests in Metabolism Pharmacology.- Safety Pharmacology in Peripheral Nervous System Drugs.- Safety Pharmacology for Intravenous and Inhalation Anesthetics.- Side effects of central analgesic drugs.- Safety Pharmacology of Anti-inflammatory drugs.- Safety Pharmacology of Drugs with Osteoarthritis-related activity.- Safety Pharmacology of Blood Constituents.- Safety Assessment of Drugs Used in Ophthalmology.- Safety Assays in Endocrine Pharmacology.- Safety Assays in Skin Pharmacology.- Safety Pharmacology in Biologics.- Magnetic Resonance Imaging in Pharmaceutical Safety Assessment.- Perspectives of Safety Pharmacology, Ongoing Initiatives and Activities, Pharmaceuticals in the Environment.- Section II Safety Pharmacokinetics: Introduction.- Absorption-ex vivo tests.- Absorption-in vitro tests-cell based.- Absorption-in vitro tests-non cell based.- Absorption-in vivo tests (radiolabeled).- Bioanalytical assays-GC.- Bioanalytical assays-LC-MS/MS.- Bioanalytical assays-RIA/ELISA.- Bioanalytical assays-Toxicokinetics.- Clinical studies-typical designs.- Distribution-across barriers.- Distribution-in vitro tests-protein binding.- Distribution-in vivo-other methods.- Distribution-in vivo-perfused organs.- Distribution-in vivo-QWBA.- Drug-drug interaction-enzyme induction.- Drug-drug interaction-enzyme inhibition.- In-silico ADME Modeling.- Metabolism-enzyme mapping.- Metabolism-in vitro stability/profiling.- Metabolism-in vivo profiling.- Pharmacogenomics in DME.- Physicochemical properties.- Population kinetics.- Typical PK/PD approaches.- Section III Safety toxicology: Introduction.- International Guidelines.- General toxicity (acute, subchronic, chronic, carcinogenicity).- In silico methods.- Alternative methods for carcinogenicity testing.- Drug Addiction in monkeys.- Genotoxicity.- Pathology.- Reproductive Toxicology.- Toxicogenomics.- Toxicoproteomics
From the contents: General Introduction: Safety Pharmacology.- Safety Pharmacokinetics.- Safety Toxicology.
From the contents: General Introduction: Safety Pharmacology.- Safety Pharmacokinetics.- Safety Toxicology.