High Quality Content by WIKIPEDIA articles! Safiyyah bint Abi al-'As was daughter of Abu al-'As ibn Umayyah. She was a wife of Abu Sufyan ibn Harb (her cousin) and bore him a daughter called Ramlah, who would later adopt Islam and marry Muhammad. She was the daughter of Saffiya bint abi al-'As and Abu Sufyan ibn Harb, the leader of Quraish and the most powerful opponent of Muhammad for most of his life. The First Ummayad ruler, Muawiyah I was her brother. Ramlah was related to Uthman ibn Affan. They were first cousins on mother's side and second cousins by her father's side.