Steven A. Julious (University of Sheffield, Sheffield, England, UK)

Sample Sizes for Clinical Trials

• Gebundenes Buch

Produktbeschreibung

This book assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them.

Produktdetails

• Verlag: Taylor & Francis Ltd
• 2 ed
• Seitenzahl: 396
• Erscheinungstermin: 21. Juni 2023
• Englisch
• Abmessung: 257mm x 182mm x 26mm
• Gewicht: 906g
• ISBN-13: 9781138587892
• ISBN-10: 1138587893
• Artikelnr.: 67402533

Autorenporträt

Steven A. Julious is a Professor of Medical Statistics at the University of Sheffield. His research interests include clinical trials, clinical trial design, early phase trials, and the development of new methodologies related to clinical trials.

Inhaltsangabe

1. Introduction. 2.Seven Key Steps to Cook up a Sample Size. 3. Sample
Sizes for Parallel Group Superiority Trials with Normal Data. 4. Sample
Size Calculations for Superiority Cross-Over Trials with Normal Data. 5.
Sample Size for Cluster Randomized Trials. 6. Allowing for Multiplicity in
Sample Sizes Calculations for Clinical Trials. 7. Samples Size Calculations
for Non-Inferiority Clinical Trials with Normal Data. 8. Sample Size
Calculations for Equivalence Clinical Trials with Normal Data. 9. Sample
Size Calculations for Bioequivalence Trials. 1. Sample Size Calculations
for Precision Clinical Trials with Normal Data. Sample Size for Pilot
Studies. 12. Sample Size Calculations for Parallel Group Superiority
Clinical Trials with Binary Data. 13. Sample Size Calculations for
Superiority Cross-Over Clinical Trials with Binary Data. 14. Sample Size
Calculations for Non-Inferiority Trials with Binary Data. 15. Sample Size
Calculations for Equivalence Trials with Binary Data. 16. Sample Size
Calculations for Precision Trials with Binary Data. 17. Sample Size
Calculations for Single Arm Clinical Trials and Studies with Finite
Population Size. 18. Sample Sizes for Clinical Trials with an Adaptive
Design. 19. Sample Size Calculations for Clinical Trials with Ordinal Data.
20. Estimating the Number of Events for Clinical Trials with Survival Data
for a Negative Outcome. 21. Sample Size Calculations for Clinical Trials
with Survival Data and a Positive Outcome. 22. Sample Size Calculations for
Clinical Trials with Survival Data Allowing for Recruitment and Withdrawal.
23. Appendix. 24. References.