Regenerative repair of elastic matrix in the AAA wall is naturally poor due to intrinsically poor elastogenicity of adult and diseased vascular SMCs [4]. In this scenario, cell therapy involving delivery of an alternate, possibly autologous cell type that would exhibit the high contractility of terminally differentiated SMCs in healthy vessels and yet exhibit the high elastogenic potential of SMC progenitor cells in early development would proffer an attractive prospect to stimulate elastogenesis lasting new elastic matrix assembly by diseased SMCs in the AAA wall . Based on prior studies in…mehr
Regenerative repair of elastic matrix in the AAA wall is naturally poor due to intrinsically poor elastogenicity of adult and diseased vascular SMCs [4]. In this scenario, cell therapy involving delivery of an alternate, possibly autologous cell type that would exhibit the high contractility of terminally differentiated SMCs in healthy vessels and yet exhibit the high elastogenic potential of SMC progenitor cells in early development would proffer an attractive prospect to stimulate elastogenesis lasting new elastic matrix assembly by diseased SMCs in the AAA wall . Based on prior studies in our lab that demonstrated superior elastogenicity of bone marrow mesenchymal stem cell (BM-MSC)-derived SMCs (BM-SMCs) and their ability to provide pro-elastogenic and anti-proteolytic stimuli to aneurysmal SMCs [5], [6], the overall goal of this study is to understand the pro-elastogenic and anti-proteolytic behavior of BM-MSCs derived SMCs in long term in vitro 2D and 3D culture, investigate their fate an in vivo rat model of induced AAA, and to seek preliminary evidence of their therapeutic efficacy for AAA treatment.
Professor Monty isn't the most suitable author for this book given their title. Typically, a vita would be written for the author, not a character within the book. Here's a vita option assuming a real author wrote the book: Isioma Okoye is a passionate writer and educator with a deep appreciation for the arts, particularly dance. Her background in [Author's background - e.g., African literature, sociology, or dance itself] fuels her work, which explores the intersection of culture, personal expression, and the transformative power of movement. "Locked Down, Grooving Out: A Nigerian Student's Dance Journey" is Isioma's captivating exploration of a young Nigerian student's experience finding solace and self-discovery through dance during a challenging time. Inspired by [Mention inspiration if any, e.g., a real-life story or a broader theme], Isioma weaves a narrative that resonates with anyone who has sought an outlet for creativity and joy in the face of adversity. Isioma's passion for storytelling extends beyond the written word. She actively participates in [Mention relevant activities, e.g., workshops, community arts programs, or dance events] to promote artistic expression and cultural exchange. Her writing is known for its vibrancy, capturing the energy and emotions of dance while offering insightful commentary on the social and cultural landscape of Nigeria. In "Locked Down, Grooving Out," Isioma offers a heartwarming and inspiring tale. She delves into the student's journey of self-expression, explores the cultural significance of dance in Nigeria, and celebrates the resilience of the human spirit. Isioma's insightful narrative equips readers to appreciate the power of dance to overcome limitations and find joy in unexpected places.
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