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Ever since Descartes identified the first task of philosophy as the defeat of scepticism, the challenge posed by scepticism has remained a central problem for epistemology. Neil Gascoigne introduces the sceptical arguments and methods of the canonical philosophers from Sextus Empiricus's Pyrrhonism to Hume before examining the so-called "therapeutic" approaches to scepticism and arguments for scepticism's apparent intractability.