Azomethine (-C=N-) group containing compounds, known as Schiff's bases, are generally formed by the reaction between primary amines and active carbonyl group bearing compounds. Schiff-base compounds have found applications in many fields, for example, as medical substrates or fine chemicals, for analysis of metal ions present in environmental samples, for extracting metallic ions etc. They have been found to effectively catalyze cyclopropanation and epoxidation reaction of alkenes and several other such reactions. Further, Schiff bases have been compounds of biological interest since long. The present book covers an account on various synthetic strategies and biological activity profile of diversely substituted Schiff base derivatives.