Endodontic therapy aims at the elimination of residual pulp, tissue breakdown products, and microorganisms present inside the root canal system, followed by hermetic filling as possible. The filling materials that do not interfere and preferably stimulate the process of apical and periapical repair must be used for sealing. An endodontic sealer should be biocompatible, antibacterial , radioopaque, insoluble in oral fluids, hermetically seal the root canal system, be dimensionally stable, should have adequate working time, easy handling, setting expansion, good adhesion to the core material and the root canal wall, should not discolor the dental tissues neither have antigenic nor mutagenic action. Recently, latest generations of silica based sealers have been introduced to the market and described by the manufacturers as a bioceramic material. In present edition an attempt has been made to clarify every phase of the subject. I request readers to critically evaluate the text and send me their comments since their analytic suggestions would help in improvement.