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This publication provides guidance to States and their competent authorities on how to implement and maintain a physical protection regime for transport of nuclear material. It will also be useful to shippers or carriers in the design and implementation of their physical protection systems. The publication builds upon the Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5), IAEA Nuclear Security Series No. 13, and provides additional guidance on how to implement these recommendations in practice.