The Seip House is a historic building on the west side of Chillicothe, Ohio, United States. Built in 1895, it is among the city's grandest houses. Born in Germany in the late 1810s, Charles Seip was a butcher who settled in the United States in 1845. Soon after crossing the Atlantic, Seip took up residence in Chillicothe; he soon began operating a butcher shop on Allen Avenue, married, and became prosperous. As his business grew, Seip expanded into downtown premises and began to purchase farms in the Chillicothe vicinity in order to supply more animals for his business.