One: Topics of General Interest.- 1 Selectivity in the service of man.- Steps in the correlation of structure with biological action.- 3 Comparative distribution: the first principle of selectivity.- 4 Comparative biochemistry: the second principle of selectivity.- 5 Comparative cytology: the third principle of selectivity.- 6 Chemotherapy: history and principles.- 7 Pharmacodynamics.- The forces available for binding an agent. Chemical bonds. Adsorption.- Two: Studies, in Depth, of Topics from Part One.- 9 Anti-metabolites: antagonistic analogues of coenzymes and enzymic substrates.- 10 Ionization.- 11 Metal-binding substances.- 12 Steric factors.- 13 The covalent bond in selective toxicity.- 14 Surface chemistry. The modification of membranes by surface-active agents.- 15 Biological activity unrelated to structure.- 16 The perfection of a discovery.- 17 Some numerical assistance.- References.- Formula index.
One: Topics of General Interest.- 1 Selectivity in the service of man.- Steps in the correlation of structure with biological action.- 3 Comparative distribution: the first principle of selectivity.- 4 Comparative biochemistry: the second principle of selectivity.- 5 Comparative cytology: the third principle of selectivity.- 6 Chemotherapy: history and principles.- 7 Pharmacodynamics.- The forces available for binding an agent. Chemical bonds. Adsorption.- Two: Studies, in Depth, of Topics from Part One.- 9 Anti-metabolites: antagonistic analogues of coenzymes and enzymic substrates.- 10 Ionization.- 11 Metal-binding substances.- 12 Steric factors.- 13 The covalent bond in selective toxicity.- 14 Surface chemistry. The modification of membranes by surface-active agents.- 15 Biological activity unrelated to structure.- 16 The perfection of a discovery.- 17 Some numerical assistance.- References.- Formula index.
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