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Centuries have passed, but human suffering from illness has remained constant. Among all suffering, depression or stress is a very common illness associated with poor performance that has reduced social functionality, the quality of life, and increased suicidal thoughts/suicides. Pharmacotherapy is the prime choice for treating depression, but it leads to severe side-effects and addiction. Beside allopathic, nowadays several new techniques or methods have been studies in search of an alternative effective and safe therapy to treat depression. In ancient times, the concept of treating this mental illness was completely different and was based on the involvement of senses such as the eye, ear, nose, skin and taste. I have tried to summarize and analyze these treatments and have documented the scientific development to date.