Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and…mehr
Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.
TABLE OF CONTENTS EPIDEMIOLOGY AND CLINICAL COURSE OF SEPSIS AND MODS Epidemiology and Clinical Course of Sepsis The Complexities of Sepsis and Organ Dysfunction SCORING SYSTEMS An Overview to Introduce Prognostic Indexes in MODS Multiple Organ Dysfunction (MOD) Score The Logistic Organ Dysfunction (LOD) System Will the Use of Scores Benefit the Individual Patient and Improve Therapy? MEDIATORS AND PROSTAGLANDINS Old and New Mediators in Sepsis. The Enigma Is Not Yet Resolved Modulating Prostaglandin Metabolism in Sepsis DO2/VO2 IN SEPSIS Oxygen Delivery and Consumption Relationships in Sepsis The Role of Inotropic and Vasoactive Drugs COAGULATION Disturbances and Modulators of Coagulation and Fibrinolysis in Sepsis EXPERIMENTAL AND CLINICAL APPROACH Therapies Directed against TNF-a and IL-1 during Sepsis Effects of Adrenergic Agents on the Hepato-Splanchnic Circulation: An Update When to Operate or to Stop Operating and to Plan a Reoperation Multiple Therapeutic Agents - Are We Making Progress? NEUROMUSCULAR DYSFUNCTION SIRS and Sepsis-Induced Neuromuscular Dysfunctions PREVENTION AND MANAGEMENT OF SEPSIS AND MODS Lights and Shadows in Sepsis and Multiple Organ Dysfunction Syndrome (MODS) INDEX
TABLE OF CONTENTS EPIDEMIOLOGY AND CLINICAL COURSE OF SEPSIS AND MODS Epidemiology and Clinical Course of Sepsis The Complexities of Sepsis and Organ Dysfunction SCORING SYSTEMS An Overview to Introduce Prognostic Indexes in MODS Multiple Organ Dysfunction (MOD) Score The Logistic Organ Dysfunction (LOD) System Will the Use of Scores Benefit the Individual Patient and Improve Therapy? MEDIATORS AND PROSTAGLANDINS Old and New Mediators in Sepsis. The Enigma Is Not Yet Resolved Modulating Prostaglandin Metabolism in Sepsis DO2/VO2 IN SEPSIS Oxygen Delivery and Consumption Relationships in Sepsis The Role of Inotropic and Vasoactive Drugs COAGULATION Disturbances and Modulators of Coagulation and Fibrinolysis in Sepsis EXPERIMENTAL AND CLINICAL APPROACH Therapies Directed against TNF-a and IL-1 during Sepsis Effects of Adrenergic Agents on the Hepato-Splanchnic Circulation: An Update When to Operate or to Stop Operating and to Plan a Reoperation Multiple Therapeutic Agents - Are We Making Progress? NEUROMUSCULAR DYSFUNCTION SIRS and Sepsis-Induced Neuromuscular Dysfunctions PREVENTION AND MANAGEMENT OF SEPSIS AND MODS Lights and Shadows in Sepsis and Multiple Organ Dysfunction Syndrome (MODS) INDEX
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